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NGL2 RNA exonuclease [ Saccharomyces cerevisiae S288C ]

Gene ID: 855329, updated on 2-Nov-2024

Summary

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Official Symbol
NGL2
Official Full Name
RNA exonuclease
Primary source
SGD:S000004898
Locus tag
YMR285C
See related
AllianceGenome:SGD:S000004898; FungiDB:YMR285C; VEuPathDB:YMR285C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA endonuclease activity. Involved in rRNA processing. Predicted to be located in cytoplasm. Orthologous to human PDE12 (phosphodiesterase 12). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See NGL2 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (840144..841691, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene tRNA-Tyr Neighboring gene ATP-dependent DNA helicase YKU70 Neighboring gene mitochondrial 54S ribosomal protein YmL33 Neighboring gene exoribonuclease II

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ngl2p is a Ccr4p-like RNA nuclease essential for the final step in 3'-end processing of 5.8S rRNA in Saccharomyces cerevisiae. Faber AW, et al. RNA, 2002 Sep. PMID 12358428, Free PMC Article
  2. The final step in 5.8S rRNA processing is cytoplasmic in Saccharomyces cerevisiae. Thomson E, et al. Mol Cell Biol, 2010 Feb. PMID 20008552, Free PMC Article
  3. Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 binding. Dupressoir A, et al. BMC Genomics, 2001. PMID 11747467, Free PMC Article
  4. Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens. Fromont-Racine M, et al. Nat Genet, 1997 Jul. PMID 9207794
  5. Annotating novel genes by integrating synthetic lethals and genomic information. Schöner D, et al. BMC Syst Biol, 2008 Jan 14. PMID 18194531, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA endonuclease activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables poly(A)-specific ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IC
Inferred by Curator
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RNA exonuclease
NP_014012.1
  • Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    840144..841691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182792.1 → NP_014012.1  TPA: RNA exonuclease [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014012.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0B2, Q03264
    UniProtKB/TrEMBL
    A6ZN01, B3LMH3, C7GTL4, C8ZFF2, G2WKZ4, N1NYU3
    Conserved Domains (1) summary
    COG5239
    Location:82 → 515
    CCR4; mRNA deadenylase, 3'-5' endonuclease subunit Ccr4 [RNA processing and modification]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03264.1

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