ZRC1 Zn(2+) transporter ZRC1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ZRC1
Official Full Name: Zn(2+) transporter ZRC1
Primary source: SGD:S000004856
Locus tag: YMR243C
See related: AllianceGenome:SGD:S000004856; FungiDB:YMR243C; VEuPathDB:YMR243C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: OSR1
Summary: Enables zinc ion transmembrane transporter activity. Involved in intracellular zinc ion homeostasis. Located in fungal-type vacuole membrane and membrane raft. Human ortholog(s) of this gene implicated in hypermanganesemia with dystonia 1. Orthologous to several human genes including SLC30A1 (solute carrier family 30 member 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ZRC1 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (754838..756166, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Several amino acid substitutions within ZRC1 were found to change its metal specificity. The substitutions that resulted in gain in Fe+ transport activity were all in transmembrane domains.
Title: Gain-of-function mutations identify amino acids within transmembrane domains of the yeast vacuolar transporter Zrc1 that determine metal specificity.
Zrc1 and Cot1 vacuolar zinc transporters control alkaline phosphatase accumulation and activity.
Title: Zinc status and vacuolar zinc transporters control alkaline phosphatase accumulation and activity in Saccharomyces cerevisiae.
analysis of how one single amino acid change in the yeast vacuolar metal transporters ZRC1 and COT1 alters their substrate specificity
Title: A single amino acid change in the yeast vacuolar metal transporters ZRC1 and COT1 alters their substrate specificity.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables monoatomic cation transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in inorganic ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular monoatomic cation homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular zinc ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular zinc ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic cation transport	IEA Inferred from Electronic Annotation more info
involved_in response to cadmium ion	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in zinc ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in zinc ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in fungal-type vacuole	IDA Inferred from Direct Assay more info	PubMed
located_in fungal-type vacuole membrane	HDA more info	PubMed
is_active_in fungal-type vacuole membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in fungal-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Zn(2+) transporter ZRC1

NP_013970.1

Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

754838..756166 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182750.1 → NP_013970.1 TPA: Zn(2+) transporter ZRC1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013970.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W070, P20107

UniProtKB/TrEMBL

A6ZMV7, B3LMD2, C7GRA8, C8ZFA9, N1NXN3

Conserved Domains (1) summary

COG1230
Location:6 → 375

CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]