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YHM2 Yhm2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855282, updated on 2-Nov-2024

Summary

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Official Symbol
YHM2
Official Full Name
Yhm2p
Primary source
SGD:S000004854
Locus tag
YMR241W
See related
AllianceGenome:SGD:S000004854; FungiDB:YMR241W; VEuPathDB:YMR241W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables DNA binding activity. Involved in alpha-ketoglutarate transport; mitochondrial citrate transmembrane transport; and mitochondrial genome maintenance. Located in mitochondrial nucleoid. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See YHM2 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (751961..752905)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene ribonuclease III Neighboring gene U2 snRNP complex subunit CUS1 Neighboring gene ribosomal 60S subunit protein L20A Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitochondrial citrate transporters Ctp1-Yhm2 and respiratory chain: A coordinated functional connection in Saccharomyces cerevisiae metabolism. De Blasi G, et al. Int J Biol Macromol, 2024 Jun. PMID 38750837
  2. A novel DNA-binding protein bound to the mitochondrial inner membrane restores the null mutation of mitochondrial histone Abf2p in Saccharomyces cerevisiae. Cho JH, et al. Mol Cell Biol, 1998 Oct. PMID 9742088, Free PMC Article
  3. Bacterial overexpression of putative yeast mitochondrial transport proteins. Mayor JA, et al. J Bioenerg Biomembr, 1997 Dec. PMID 9559855
  4. Identification and functional characterization of a novel mitochondrial carrier for citrate and oxoglutarate in Saccharomyces cerevisiae. Castegna A, et al. J Biol Chem, 2010 Jun 4. PMID 20371607, Free PMC Article
  5. Three mitochondrial transporters of Saccharomyces cerevisiae are essential for ammonium fixation and lysine biosynthesis in synthetic minimal medium. Scarcia P, et al. Mol Genet Metab, 2017 Nov. PMID 28784321

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mitochondrial citrate transporters Ctp1-Yhm2 and respiratory chain: A coordinated functional connection in Saccharomyces cerevisiae metabolism.
    Title: Mitochondrial citrate transporters Ctp1-Yhm2 and respiratory chain: A coordinated functional connection in Saccharomyces cerevisiae metabolism.
  2. Yhm2p is a mitochondrial transporter for citrate and oxoglutarate
    Title: Identification and functional characterization of a novel mitochondrial carrier for citrate and oxoglutarate in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in alpha-ketoglutarate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in alpha-ketoglutarate transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial citrate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial citrate transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial genome maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitochondrial genome maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tricarboxylic acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial nucleoid IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Yhm2p
NP_013968.1
  • Citrate and oxoglutarate carrier protein; exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    751961..752905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182748.1 → NP_013968.1  TPA: Yhm2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013968.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W067, Q04013
    UniProtKB/TrEMBL
    A6ZMV4, B3LMC9, B5VQ10, C7GRB0, C8ZFA6, G2WKU9, N1P0L2
    Conserved Domains (1) summary
    pfam00153
    Location:211 → 305
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04013.1

Gene LinkOut

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