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DFG5 putative mannan endo-1,6-alpha-mannosidase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855278, updated on 2-Nov-2024

Summary

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Official Symbol
DFG5
Official Full Name
putative mannan endo-1,6-alpha-mannosidase
Primary source
SGD:S000004851
Locus tag
YMR238W
See related
AllianceGenome:SGD:S000004851; FungiDB:YMR238W; VEuPathDB:YMR238W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable mannan endo-1,6-alpha-mannosidase activity. Involved in budding cell bud growth; fungal-type cell wall biogenesis; and pseudohyphal growth. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See DFG5 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (746353..747729)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene chromatin modification protein Neighboring gene exomer complex subunit Neighboring gene tRNA-Arg Neighboring gene ribonuclease III

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two homologous genes, DCW1 (YKL046c) and DFG5, are essential for cell growth and encode glycosylphosphatidylinositol (GPI)-anchored membrane proteins required for cell wall biogenesis in Saccharomyces cerevisiae. Kitagaki H, et al. Mol Microbiol, 2002 Nov. PMID 12421307
  2. A temperature-sensitive dcw1 mutant of Saccharomyces cerevisiae is cell cycle arrested with small buds which have aberrant cell walls. Kitagaki H, et al. Eukaryot Cell, 2004 Oct. PMID 15470258, Free PMC Article
  3. Systematic genetic modifications of cell wall biosynthesis enhanced the secretion and surface-display of polysaccharide degrading enzymes in Saccharomyces cerevisiae. Chen N, et al. Metab Eng, 2023 May. PMID 37100192
  4. Signaling alkaline pH stress in the yeast Saccharomyces cerevisiae through the Wsc1 cell surface sensor and the Slt2 MAPK pathway. Serrano R, et al. J Biol Chem, 2006 Dec 29. PMID 17088254
  5. Loss of Dfg5 glycosylphosphatidylinositol-anchored membrane protein confers enhanced heat tolerance in Saccharomyces cerevisiae. Nasution O, et al. Environ Microbiol, 2015 Aug. PMID 25297926

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a model is proposed on the signal transduction pathways associated with deletion of DFG5 upon heat stress.
    Title: Loss of Dfg5 glycosylphosphatidylinositol-anchored membrane protein confers enhanced heat tolerance in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables mannan endo-1,6-alpha-mannosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in budding cell bud growth IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in budding cell bud growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in carbohydrate catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in fungal-type cell wall biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fungal-type cell wall biogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pseudohyphal growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative mannan endo-1,6-alpha-mannosidase
NP_013965.1
  • Putative mannosidase; essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    746353..747729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182745.1 → NP_013965.1  TPA: putative mannan endo-1,6-alpha-mannosidase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013965.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W064, Q05031
    UniProtKB/TrEMBL
    A6ZMV1, B3LMC6, B5VQ07, C7GRB3, C8ZFA3, G2WKU6, N1NYP3
    Conserved Domains (1) summary
    pfam03663
    Location:36 → 385
    Glyco_hydro_76; Glycosyl hydrolase family 76
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05031.1

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