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ESC1 Esc1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855259, updated on 18-Sep-2024

Summary

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Official Symbol
ESC1
Official Full Name
Esc1p
Primary source
SGD:S000004832
Locus tag
YMR219W
See related
AllianceGenome:SGD:S000004832; FungiDB:YMR219W; VEuPathDB:YMR219W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in subtelomeric heterochromatin assembly and telomere tethering at nuclear periphery. Located in chromosome, telomeric region and nuclear periphery. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ESC1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (707133..712109)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene GMP synthase (glutamine-hydrolyzing) Neighboring gene transport protein particle complex II subunit TRS130 Neighboring gene phosphomevalonate kinase Neighboring gene Fmp42p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Immobility, inheritance and plasticity of shape of the yeast nucleus. Hattier T, et al. BMC Cell Biol, 2007 Nov 9. PMID 17996101, Free PMC Article
  2. The functional importance of telomere clustering: global changes in gene expression result from SIR factor dispersion. Taddei A, et al. Genome Res, 2009 Apr. PMID 19179643, Free PMC Article
  3. Discovery and Evolution of New Domains in Yeast Heterochromatin Factor Sir4 and Its Partner Esc1. Faure G, et al. Genome Biol Evol, 2019 Feb 1. PMID 30668669, Free PMC Article
  4. Elevated dosage of Ulp1 disrupts telomeric silencing in Saccharomyces cerevisiae. Abraham NM, et al. Mol Biol Rep, 2018 Dec. PMID 30357586
  5. Separation of silencing from perinuclear anchoring functions in yeast Ku80, Sir4 and Esc1 proteins. Taddei A, et al. EMBO J, 2004 Mar 24. PMID 15014445, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Esc1-interacting region of Sir4 is Dbf4-related H-BRCT domain
    Title: Discovery and Evolution of New Domains in Yeast Heterochromatin Factor Sir4 and Its Partner Esc1.
  2. Data show that Esc1 and Ulp1 help retain unspliced pre-mRNAs in the nucleus, and are essential for proper nuclear basket function, which includes mRNA surveillance and regulation of SUMO protein dynamics.
    Title: A nuclear envelope protein linking nuclear pore basket assembly, SUMO protease regulation, and mRNA surveillance.
  3. Ku- and Esc1-dependent pathways mediate natural telomere anchoring in vivo
    Title: Separation of silencing from perinuclear anchoring functions in yeast Ku80, Sir4 and Esc1 proteins.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in subtelomeric heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere tethering at nuclear periphery IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear periphery IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Esc1p
NP_013946.1
  • Protein involved in telomeric silencing; required for quiescent cell telomere hypercluster localization at nuclear membrane vicinity; interacts with PAD4-domain of Sir4p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    707133..712109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182726.1 → NP_013946.1  TPA: Esc1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013946.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W044, Q03661, Q04988
    UniProtKB/TrEMBL
    B3LMA7
    Conserved Domains (2) summary
    COG5271
    Location:945 → 1502
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    TIGR00927
    Location:175 → 442
    2A1904; K+-dependent Na+/Ca+ exchanger
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03661.1

Gene LinkOut

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