GUA1 GMP synthase (glutamine-hydrolyzing) [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: GUA1
Official Full Name: GMP synthase (glutamine-hydrolyzing)
Primary source: SGD:S000004830
Locus tag: YMR217W
See related: AllianceGenome:SGD:S000004830; FungiDB:YMR217W; VEuPathDB:YMR217W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables GMP synthase (glutamine-hydrolyzing) activity. Involved in GMP biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in acute myelomonocytic leukemia. Orthologous to human GMPS (guanine monophosphate synthase). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Interactions of GMP with Human Glrx3 and with Saccharomyces cerevisiae Grx3 and Grx4 Converge in the Regulation of the Gcn2 Pathway.
Title: Interactions of GMP with Human Glrx3 and with Saccharomyces cerevisiae Grx3 and Grx4 Converge in the Regulation of the Gcn2 Pathway.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GMP synthase (glutamine-hydrolyzing) activity	IEA Inferred from Electronic Annotation more info
enables GMP synthase (glutamine-hydrolyzing) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables GMP synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GMP synthase activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in GMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in GMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GMP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in GMP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glutamine metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info

NP_013944.1

GMP synthase; highly conserved enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation; reduction-of-function mutation gua1-G388D causes changes in cellular guanine nucleotide pools, defects in general protein synthesis, and impaired translation of GCN4 mRNA