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CLN1 cyclin CLN1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855239, updated on 14-Nov-2024

Summary

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Official Symbol
CLN1
Official Full Name
cyclin CLN1
Primary source
SGD:S000004812
Locus tag
YMR199W
See related
AllianceGenome:SGD:S000004812; FungiDB:YMR199W; VEuPathDB:YMR199W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in regulation of protein phosphorylation and traversing start control point of mitotic cell cycle. Located in cytoplasm and nucleus. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); endocrine gland cancer (multiple); hematologic cancer (multiple); and hepatitis B. Orthologous to several human genes including CCNA1 (cyclin A1); CCNA2 (cyclin A2); and CCND1 (cyclin D1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CLN1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (662644..664284)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene v-SNARE protein VTI1 Neighboring gene Cik1p Neighboring gene Rot1p Neighboring gene DNA repair protein RAD14

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Repression of growth-regulated G1 cyclin expression by cyclic AMP in budding yeast. Baroni MD, et al. Nature, 1994 Sep 22. PMID 8090203
  2. Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle. Amon A, et al. Cell, 1994 Jul 1. PMID 8020094
  3. Control of yeast filamentous-form growth by modules in an integrated molecular network. Prinz S, et al. Genome Res, 2004 Mar. PMID 14993204, Free PMC Article
  4. An enhancer trap line associated with a D-class cyclin gene in Arabidopsis. Swaminathan K, et al. Plant Physiol, 2000 Dec. PMID 11115883, Free PMC Article
  5. CLN1 and its repression by Xbp1 are important for efficient sporulation in budding yeast. Mai B, et al. Mol Cell Biol, 2000 Jan. PMID 10611226, Free PMC Article

See all (200) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The global role of cyclin-specific phosphorylation has been resolved whereby a cyclin docking motif, LxF, that mediates binding of replication factor Cdc6 to mitotic cyclin has been uncovered.
    Title: Cyclin-Specific Docking Mechanisms Reveal the Complexity of M-CDK Function in the Cell Cycle.
  2. The region between amino acids 225 and 299 of Cln2 is sufficient to confer Cln2-specific functionality to Cln1.
    Title: Molecular basis of the functional distinction between Cln1 and Cln2 cyclins.
  3. Ime2 does not directly catalyze Sic1 phosphorylation to target it for destabilization as Cln1,-2/Cdk1 do during the cell cycle
    Title: Yeast IME2 functions early in meiosis upstream of cell cycle-regulated SBF and MBF targets.
  4. positive-feedback-amplified expression of Cln1 and Cln2 simultaneously drives robust budding and rapid, coherent regulon expression
    Title: Positive feedback of G1 cyclins ensures coherent cell cycle entry.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in traversing start control point of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cyclin CLN1
NP_013926.1
  • G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p); CLN1 has a paralog, CLN2, that arose from the whole genome duplication; cell cycle arrest phenotype of the cln1 cln2 cln3 triple null mutant is complemented by any of human cyclins CCNA2, CCNB1, CCNC, CCND1, or CCNE1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    662644..664284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182706.1 → NP_013926.1  TPA: cyclin CLN1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013926.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W024, P20437
    UniProtKB/TrEMBL
    A6ZMR1, B3LM87, B5VPW8, C7GRF2, N1NYY9
    Conserved Domains (1) summary
    COG5024
    Location:31 → 539
    COG5024; Cyclin [Cell division and chromosome partitioning]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20437.2

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