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DDR48 DNA damage-responsive protein 48 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855210, updated on 2-Nov-2024

Summary

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Official Symbol
DDR48
Official Full Name
DNA damage-responsive protein 48
Primary source
SGD:S000004784
Locus tag
YMR173W
See related
AllianceGenome:SGD:S000004784; FungiDB:YMR173W; VEuPathDB:YMR173W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ATP hydrolysis activity and GTPase activity. Involved in DNA repair. Located in cytosol. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See DDR48 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (608689..609981)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Ear1p Neighboring gene Hot1p Neighboring gene Pai3p Neighboring gene Sip18p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of the DNA damage-inducible gene DDR48 and evidence for its role in mutagenesis in Saccharomyces cerevisiae. Treger JM, et al. Mol Cell Biol, 1990 Jun. PMID 2111448, Free PMC Article
  2. Purification and characterization of Saccharomyces cerevisiae DNA damage-responsive protein 48 (DDRP 48). Sheng S, et al. J Biol Chem, 1993 Mar 5. PMID 8444852
  3. DNA damage and heat shock dually regulate genes in Saccharomyces cerevisiae. McClanahan T, et al. Mol Cell Biol, 1986 Jan. PMID 3023840, Free PMC Article
  4. Transcriptional regulation of DNA damage responsive (DDR) genes in different rad mutant strains of Saccharomyces cerevisiae. Maga JA, et al. Mol Gen Genet, 1986 Nov. PMID 3100912
  5. Yeast adapts to a changing stressful environment by evolving cross-protection and anticipatory gene regulation. Dhar R, et al. Mol Biol Evol, 2013 Mar. PMID 23125229

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytosol HDA PubMed 

General protein information

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Preferred Names
DNA damage-responsive protein 48
NP_013897.1
  • DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    608689..609981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182678.1 → NP_013897.1  TPA: DNA damage-responsive protein 48 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013897.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZZ5, P18899
    UniProtKB/TrEMBL
    A6ZMN2
    Conserved Domains (2) summary
    PTZ00110
    Location:327 → 393
    PTZ00110; helicase; Provisional
    NF033849
    Location:80 → 357
    ser_rich_anae_1; serine-rich protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18899.4

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