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HLJ1 type I HSP40 co-chaperone HLJ1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855196, updated on 2-Nov-2024

Summary

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Official Symbol
HLJ1
Official Full Name
type I HSP40 co-chaperone HLJ1
Primary source
SGD:S000004771
Locus tag
YMR161W
See related
AllianceGenome:SGD:S000004771; FungiDB:YMR161W; VEuPathDB:YMR161W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ATPase activator activity. Involved in ERAD pathway. Located in endoplasmic reticulum membrane. Used to study Huntington's disease. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy type 1 and autosomal recessive distal hereditary motor neuronopathy 5. Orthologous to several human genes including DNAJB12 (DnaJ heat shock protein family (Hsp40) member B12). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See HLJ1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (577718..578392)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Atg16p Neighboring gene Cvm1p Neighboring gene aminophospholipid-translocating P4-type ATPase DNF3 Neighboring gene Inp2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Distinct roles for the Hsp40 and Hsp90 molecular chaperones during cystic fibrosis transmembrane conductance regulator degradation in yeast. Youker RT, et al. Mol Biol Cell, 2004 Nov. PMID 15342786, Free PMC Article
  2. The mammalian Hsp40 ERdj3 requires its Hsp70 interaction and substrate-binding properties to complement various yeast Hsp40-dependent functions. Vembar SS, et al. J Biol Chem, 2009 Nov 20. PMID 19748898, Free PMC Article
  3. Chaperone-mediated reflux of secretory proteins to the cytosol during endoplasmic reticulum stress. Igbaria A, et al. Proc Natl Acad Sci U S A, 2019 Jun 4. PMID 31101715, Free PMC Article
  4. Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein. Huyer G, et al. J Biol Chem, 2004 Sep 10. PMID 15252059
  5. COPII machinery cooperates with ER-localized Hsp40 to sequester misfolded membrane proteins into ER-associated compartments. Kakoi S, et al. Mol Biol Cell, 2013 Mar. PMID 23303252, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
type I HSP40 co-chaperone HLJ1
NP_013884.1
  • Co-chaperone for Hsp40p; anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    577718..578392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182665.1 → NP_013884.1  TPA: type I HSP40 co-chaperone HLJ1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013884.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZY3, P48353
    UniProtKB/TrEMBL
    A6ZMM0, B3LM49, B5VPT1, C7GU61, C8ZF21, G2WKL4, N1NXG1
    Conserved Domains (1) summary
    TIGR02349
    Location:22 → 154
    DnaJ_bact; chaperone protein DnaJ
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48353.1

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