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STO1 Sto1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855155, updated on 3-Nov-2024

Summary

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Official Symbol
STO1
Official Full Name
Sto1p
Primary source
SGD:S000004732
Locus tag
YMR125W
See related
AllianceGenome:SGD:S000004732; FungiDB:YMR125W; VEuPathDB:YMR125W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CBC1; CBP80; GCR3; SUT1
Summary
Enables mRNA binding activity. Involved in mRNA splicing, via spliceosome; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; and response to osmotic stress. Located in nucleus. Part of commitment complex and nuclear cap binding activity complex. Orthologous to human NCBP1 (nuclear cap binding protein subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See STO1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
2
Sequence:
Chromosome: XIII; NC_001145.3 (517539..520446)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Pkr1p Neighboring gene Epo1p Neighboring gene Dlt1p Neighboring gene histone acetyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GCR3 encodes an acidic protein that is required for expression of glycolytic genes in Saccharomyces cerevisiae. Uemura H, et al. J Bacteriol, 1992 Sep. PMID 1512188, Free PMC Article
  2. A yeast cap binding protein complex (yCBC) acts at an early step in pre-mRNA splicing. Lewis JD, et al. Nucleic Acids Res, 1996 Sep 1. PMID 8811086, Free PMC Article
  3. Mutations in GCR3, a gene involved in the expression of glycolytic genes in Saccharomyces cerevisiae, suppress the temperature-sensitive growth of hpr1 mutants. Uemura H, et al. Genetics, 1996 Apr. PMID 8846890, Free PMC Article
  4. Yeast mRNA cap-binding protein Cbc1/Sto1 is necessary for the rapid reprogramming of translation after hyperosmotic shock. Garre E, et al. Mol Biol Cell, 2012 Jan. PMID 22072789, Free PMC Article
  5. RPL30 regulation of splicing reveals distinct roles for Cbp80 in U1 and U2 snRNP cotranscriptional recruitment. Bragulat M, et al. RNA, 2010 Oct. PMID 20801768, Free PMC Article

See all (113) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. our results indicate that binding of Cbc1 to the capped mRNAs is necessary for the accumulation of specific activators as well as PIC components at the promoters of genes whose expression requires high and rapid transcription.
    Title: The mRNA cap-binding protein Cbc1 is required for high and timely expression of genes by promoting the accumulation of gene-specific activators at promoters.
  2. Cbc1-mediated translation is necessary for the rapid translation of osmostress-protective proteins under osmotic stress
    Title: Yeast mRNA cap-binding protein Cbc1/Sto1 is necessary for the rapid reprogramming of translation after hyperosmotic shock.
  3. Cbp80 plays distinct roles in the recognition of the intron by U1 and U2 snRNP.
    Title: RPL30 regulation of splicing reveals distinct roles for Cbp80 in U1 and U2 snRNP cotranscriptional recruitment.
  4. searched for additional, novel targets of Prp28p. A screen identified Prp42p, Snu71p, and Cbp80p, all known components of commitment complexes, as well as Ynl187p, a protein of uncertain function.
    Title: A targeted bypass screen identifies Ynl187p, Prp42p, Snu71p, and Cbp80p for stable U1 snRNP/Pre-mRNA interaction.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA cap binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA cap binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding HDA PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in 7-methylguanosine mRNA capping IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA export from nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
Inferred from Electronic Annotation
more info
  
involved_in response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of commitment complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear cap binding complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear cap binding complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear cap binding complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Sto1p
NP_013844.2
  • Large subunit of the nuclear mRNA cap-binding protein complex; interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    517539..520446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182626.1 → NP_013844.2  TPA: Sto1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013844.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZU8, P34160
    UniProtKB/TrEMBL
    A6ZMI5, B3LM16, C8ZEY0
    Conserved Domains (3) summary
    pfam09088
    Location:346 → 541
    MIF4G_like; MIF4G like
    pfam02854
    Location:36 → 264
    MIF4G; MIF4G domain
    pfam09090
    Location:581 → 828
    MIF4G_like_2; MIF4G like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34160.2

Gene LinkOut

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