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MED11 Med11p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855139, updated on 18-Sep-2024

Summary

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Official Symbol
MED11
Official Full Name
Med11p
Primary source
SGD:S000004718
Locus tag
YMR112C
See related
AllianceGenome:SGD:S000004718; FungiDB:YMR112C; VEuPathDB:YMR112C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables TFIIH-class transcription factor complex binding activity and transcription coactivator activity. Involved in RNA polymerase II preinitiation complex assembly; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Part of core mediator complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MED11 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (494100..494495, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene hexadecenal dehydrogenase Neighboring gene Euc1p Neighboring gene dihydrofolate synthase Neighboring gene putative peptide hydrolase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of new mediator subunits in the RNA polymerase II holoenzyme from Saccharomyces cerevisiae. Gustafsson CM, et al. J Biol Chem, 1998 Nov 20. PMID 9812975
  2. Architecture of the Mediator head module. Imasaki T, et al. Nature, 2011 Jul 3. PMID 21725323, Free PMC Article
  3. Mediator structural conservation and implications for the regulation mechanism. Cai G, et al. Structure, 2009 Apr 15. PMID 19368889, Free PMC Article
  4. Mediator head subcomplex Med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization. Seizl M, et al. Nucleic Acids Res, 2011 Aug. PMID 21498544, Free PMC Article
  5. The classical srb4-138 mutant allele causes dissociation of yeast Mediator. Linder T, et al. Biochem Biophys Res Commun, 2006 Oct 27. PMID 16962561

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables TFIIH-class transcription factor complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of core mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Med11p
NP_013830.1
  • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    494100..494495 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182612.1 → NP_013830.1  TPA: Med11p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013830.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A6ZMG9, B3LM03, C7GW97, C8ZEW5, G2WKG2, N1NYD6
    Conserved Domains (1) summary
    pfam10280
    Location:23 → 125
    Med11; Mediator complex protein
Nucleotide Protein
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