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CTF13 Ctf13p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855119, updated on 2-Nov-2024

Summary

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Official Symbol
CTF13
Official Full Name
Ctf13p
Primary source
SGD:S000004700
Locus tag
YMR094W
See related
AllianceGenome:SGD:S000004700; FungiDB:YMR094W; VEuPathDB:YMR094W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables DNA binding activity, bending. Involved in kinetochore assembly and septin ring assembly. Part of CBF3 complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CTF13 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (455825..457261)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Aip1p Neighboring gene snoRNA-binding rRNA-processing protein UTP15 Neighboring gene putative pyridoxal 5'-phosphate synthase Neighboring gene pyridoxine biosynthesis protein SNZ1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of essential components of the S. cerevisiae kinetochore. Doheny KF, et al. Cell, 1993 May 21. PMID 8500169, Free PMC Article
  2. A 240 kd multisubunit protein complex, CBF3, is a major component of the budding yeast centromere. Lechner J, et al. Cell, 1991 Feb 22. PMID 1997204
  3. Mutations in the yeast cyclin-dependent kinase Cdc28 reveal a role in the spindle assembly checkpoint. Kitazono AA, et al. Mol Genet Genomics, 2003 Aug. PMID 12827501
  4. A case of convergent-gene interference in the budding yeast knockout library causing chromosome instability. Gordon MR, et al. G3 (Bethesda), 2021 May 7. PMID 33724427, Free PMC Article
  5. Yeast kinetochores do not stabilize Stu2p-dependent spindle microtubule dynamics. Pearson CG, et al. Mol Biol Cell, 2003 Oct. PMID 14517328, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CBF3 acts as a passenger protein to coordinate chromosome segregation with cytokinesis
    Title: A novel role for the CBF3 kinetochore-scaffold complex in regulating septin dynamics and cytokinesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding, bending IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in kinetochore assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in septin ring assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of CBF3 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ctf13p
NP_013812.1
  • Subunit of the CBF3 complex; F-box protein of the leucine-rich-repeat family; required for assembly of the complex; CBF3 binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    455825..457261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182594.1 → NP_013812.1  TPA: Ctf13p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013812.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZR7, P35203
    UniProtKB/TrEMBL
    A6ZMF1, B3LLY5, C7GL32, C8ZEU6, N1P5I4
    Conserved Domains (1) summary
    cd19611
    Location:163 → 477
    Ctf13_LRR_LRR-insertion; leucine-rich-repeat (LRR) domain and LRR insertion domain of centromere DNA-binding protein complex CBF3 subunit C (Ctf13)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35203.3

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