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MOT3 Mot3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855092, updated on 2-Nov-2024

Summary

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Official Symbol
MOT3
Official Full Name
Mot3p
Primary source
SGD:S000004674
Locus tag
YMR070W
See related
AllianceGenome:SGD:S000004674; FungiDB:YMR070W; VEuPathDB:YMR070W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ROX7
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in cellular hyperosmotic response; negative regulation of ergosterol biosynthetic process; and regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MOT3 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (409154..410626)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Avo2p Neighboring gene N-terminal L-serine N(alpha)-acetyltransferase NatD Neighboring gene Tvp18p Neighboring gene DNA-binding protein ABF2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mot3, a Zn finger transcription factor that modulates gene expression and attenuates mating pheromone signaling in Saccharomyces cerevisiae. Grishin AV, et al. Genetics, 1998 Jun. PMID 9611199, Free PMC Article
  2. The flocculant Saccharomyces cerevisiae strain gains robustness via alteration of the cell wall hydrophobicity. Kahar P, et al. Metab Eng, 2022 Jul. PMID 35257867
  3. Common and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast. Gibney PA, et al. Mol Biol Cell, 2018 Apr 15. PMID 29444955, Free PMC Article
  4. Heritable remodeling of yeast multicellularity by an environmentally responsive prion. Holmes DL, et al. Cell, 2013 Mar 28. PMID 23540696, Free PMC Article
  5. Combinatorial repression of the hypoxic genes of Saccharomyces cerevisiae by DNA binding proteins Rox1 and Mot3. Klinkenberg LG, et al. Eukaryot Cell, 2005 Apr. PMID 15821125, Free PMC Article

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The flocculant Saccharomyces cerevisiae strain gains robustness via alteration of the cell wall hydrophobicity.
    Title: The flocculant Saccharomyces cerevisiae strain gains robustness via alteration of the cell wall hydrophobicity.
  2. Both Mot3 and Msn4 bind directly to some promoter regions osmostress-inducible genes.
    Title: Activator and repressor functions of the Mot3 transcription factor in the osmostress response of Saccharomyces cerevisiae.
  3. Study reports that a prion formed by the Mot3 transcription factor, [MOT3(+)], governs the acquisition of facultative multicellularity in the budding yeast Saccharomyces cerevisiae.
    Title: Heritable remodeling of yeast multicellularity by an environmentally responsive prion.
  4. Mot3 and Rox1 are important for growth and modulation of ergosterol levels upon salt stress. Hog1, Mot3, and Rox1 repress ERG gene expression during osmotic stress.
    Title: Repression of ergosterol biosynthesis is essential for stress resistance and is mediated by the Hog1 MAP kinase and the Mot3 and Rox1 transcription factors.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular hyperosmotic response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of ergosterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mot3p
NP_013786.1
  • Transcriptional repressor, activator; role in cellular adjustment to osmotic stress including modulation of mating efficiency; involved in repression of subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of Tup1p-Cyc8p general repressor to promoters; relocalizes to cytosol under hypoxia; forms [MOT3+] prion under anaerobic conditions

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    409154..410626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182568.1 → NP_013786.1  TPA: Mot3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013786.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZP4, P54785
    UniProtKB/TrEMBL
    N1NX95
    Conserved Domains (2) summary
    COG5048
    Location:61 → 413
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00019
    Location:348 → 368
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54785.1

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