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AVO2 Avo2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855090, updated on 2-Nov-2024

Summary

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Official Symbol
AVO2
Official Full Name
Avo2p
Primary source
SGD:S000004672
Locus tag
YMR068W
See related
AllianceGenome:SGD:S000004672; FungiDB:YMR068W; VEuPathDB:YMR068W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in establishment or maintenance of actin cytoskeleton polarity and regulation of cell growth. Located in plasma membrane. Part of TORC2 complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See AVO2 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (406304..407584)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Sov1p Neighboring gene Ubx4p Neighboring gene N-terminal L-serine N(alpha)-acetyltransferase NatD Neighboring gene Mot3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dysfunction of Avo3, an essential component of target of rapamycin complex 2, induces ubiquitin-proteasome-dependent downregulation of Avo2 in Saccharomyces cerevisiae. Chen PK, et al. Biochem Biophys Res Commun, 2024 Jul 12. PMID 38718572
  2. Molecular organization of target of rapamycin complex 2. Wullschleger S, et al. J Biol Chem, 2005 Sep 2. PMID 16002396
  3. Analysis of the roles of phosphatidylinositol-4,5-bisphosphate and individual subunits in assembly, localization, and function of Saccharomyces cerevisiae target of rapamycin complex 2. Martinez Marshall MN, et al. Mol Biol Cell, 2019 Jun 1. PMID 30969890, Free PMC Article
  4. TORC2 and eisosomes are spatially interdependent, requiring optimal level of phosphatidylinositol 4, 5-bisphosphate for their integrity. Bartlett K, et al. J Biosci, 2015 Jun. PMID 25963258
  5. Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling. Pan Y, et al. Cell Metab, 2011 Jun 8. PMID 21641548, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dysfunction of Avo3, an essential component of target of rapamycin complex 2, induces ubiquitin-proteasome-dependent downregulation of Avo2 in Saccharomyces cerevisiae.
    Title: Dysfunction of Avo3, an essential component of target of rapamycin complex 2, induces ubiquitin-proteasome-dependent downregulation of Avo2 in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in establishment or maintenance of actin cytoskeleton polarity IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in regulation of cell growth IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of TORC2 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytosol HDA PubMed 
located_in nucleus HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Avo2p
NP_013784.1
  • Subunit of TORC2, a regulator of plasma membrane (PM) homeostasis; TORC2 also regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; PM retention is dependent on Avo3p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    406304..407584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182566.1 → NP_013784.1  TPA: Avo2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013784.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZP2, Q04749
    UniProtKB/TrEMBL
    A6ZMC7, B3LLW1, C7GL56, C8ZES0, N1P087
    Conserved Domains (3) summary
    COG0666
    Location:37 → 185
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:75 → 106
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:9 → 60
    Ank_4; Ankyrin repeats (many copies)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04749.1

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