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KAR5 Kar5p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855087, updated on 2-Nov-2024

Summary

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Official Symbol
KAR5
Official Full Name
Kar5p
Primary source
SGD:S000004669
Locus tag
YMR065W
See related
AllianceGenome:SGD:S000004669; FungiDB:YMR065W; VEuPathDB:YMR065W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
FIG3
Summary
Involved in karyogamy involved in conjugation with cellular fusion. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See KAR5 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (399702..401216)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Rim9p Neighboring gene Aep1p Neighboring gene Sov1p Neighboring gene Ubx4p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. KAR5 encodes a novel pheromone-inducible protein required for homotypic nuclear fusion. Beh CT, et al. J Cell Biol, 1997 Dec 1. PMID 9382856, Free PMC Article
  2. Dynamic assembly of brambleberry mediates nuclear envelope fusion during early development. Abrams EW, et al. Cell, 2012 Aug 3. PMID 22863006, Free PMC Article
  3. Prm3p is a pheromone-induced peripheral nuclear envelope protein required for yeast nuclear fusion. Shen S, et al. Mol Biol Cell, 2009 May. PMID 19297527, Free PMC Article
  4. Distinct roles for key karyogamy proteins during yeast nuclear fusion. Melloy P, et al. Mol Biol Cell, 2009 Sep. PMID 19570912, Free PMC Article
  5. Pheromone-regulated genes required for yeast mating differentiation. Erdman S, et al. J Cell Biol, 1998 Feb 9. PMID 9456310, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kar5p is required for multiple functions in both inner and outer nuclear envelope fusion in Saccharomyces cerevisiae
    Title: Kar5p is required for multiple functions in both inner and outer nuclear envelope fusion in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in karyogamy IEA
Inferred from Electronic Annotation
more info
  
involved_in karyogamy involved in conjugation with cellular fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in karyogamy involved in conjugation with cellular fusion IEA
Inferred from Electronic Annotation
more info
  
involved_in karyogamy involved in conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear membrane fusion involved in karyogamy IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Kar5p
NP_013781.1
  • Protein required for nuclear membrane fusion during karyogamy; localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; similar to zebrafish Brambleberry protein; expression of the gene is regulated by pheromone

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    399702..401216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182563.1 → NP_013781.1  TPA: Kar5p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013781.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZMC4, D6VZN9, Q04746
    UniProtKB/TrEMBL
    B3LLV8, C7GL59, C8ZER7, N1NX86
    Conserved Domains (1) summary
    pfam04163
    Location:2 → 504
    Tht1; Tht1-like nuclear fusion protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04746.1

Gene LinkOut

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