MIH1 putative tyrosine protein phosphatase MIH1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MIH1
Official Full Name: putative tyrosine protein phosphatase MIH1
Primary source: SGD:S000004639
Locus tag: YMR036C
See related: AllianceGenome:SGD:S000004639; FungiDB:YMR036C; VEuPathDB:YMR036C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable protein tyrosine phosphatase activity. Involved in G2/M transition of mitotic cell cycle and regulation of cyclin-dependent protein serine/threonine kinase activity. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive polycystic kidney disease; cervical cancer; endometrial cancer; prostate cancer; and urinary bladder cancer. Orthologous to several human genes including CDC25A (cell division cycle 25A). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MIH1 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (341856..343520, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Swe1 and the Polo-like kinase Cdc5 control the balance between phosphorylated and unphosphorylated forms of Mih1, which is, in turn, important for mitotic spindle elongation.
Title: Swe1 and Mih1 regulate mitotic spindle dynamics in budding yeast via Bik1.
Mih1 directly modulates the phosphorylation state of the Vps26 retromer subunit; mutations engineered to mimic these states modulate the binding affinities of Vps26 for a retromer cargo, resulting in corresponding changes in cargo sorting at the endosome.
Title: A CDC25 family protein phosphatase gates cargo recognition by the Vps26 retromer subunit.
Ptp1 and PP2ARts1 work redundantly with Mih1 to regulate Cdk1-Y19 dephosphorylation
Title: Redundant Regulation of Cdk1 Tyrosine Dephosphorylation in Saccharomyces cerevisiae.
The Mih1 is negatively regulated by Pkc1-mediated phosphorylation, which excludes it from the nucleus under certain conditions.
Title: Mih1/Cdc25 is negatively regulated by Pkc1 in Saccharomyces cerevisiae.
Because casein kinase 1 is associated with sites of polar growth, it may regulate Mih1 as part of a signaling mechanism that links successful completion of growth-related events to cell cycle progression.
Title: Regulation of Mih1/Cdc25 by protein phosphatase 2A and casein kinase 1.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of G2/MI transition of meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell cycle G2/M phase transition	IEA Inferred from Electronic Annotation more info
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spindle elongation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: putative tyrosine protein phosphatase MIH1

NP_013750.1

EC 3.1.3.48

Protein tyrosine phosphatase; involved in cell cycle control and retrograde protein transport; regulates the phosphorylation state of Cdc28p; modulates phosphorylation of retromer component Vps26p; homolog of S. pombe cdc25

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

341856..343520 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182533.1 → NP_013750.1 TPA: putative tyrosine protein phosphatase MIH1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013750.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZL1, P23748

UniProtKB/TrEMBL

B3LLT5, C7GL83, C8ZEP3, N1P070

Conserved Domains (1) summary

COG5105
Location:1 → 442

MIH1; Mitotic inducer, protein phosphatase [Cell division and chromosome partitioning]