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MIX17 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855014, updated on 11-Sep-2024

Summary

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Official Symbol
MIX17
Primary source
SGD:S000004604
Locus tag
YMR002W
See related
AllianceGenome:SGD:S000004604; FungiDB:YMR002W; VEuPathDB:YMR002W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MIC17
Summary
Involved in aerobic respiration. Located in mitochondrial intermembrane space. Human ortholog(s) of this gene implicated in Parkinson's disease 22 and frontotemporal dementia and/or amyotrophic lateral sclerosis-2. Orthologous to several human genes including CHCHD10 (coiled-coil-helix-coiled-coil-helix domain containing 10). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (272193..272663)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene polo kinase CDC5 Neighboring gene uncharacterized protein Neighboring gene Aim34p Neighboring gene Mvp1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel mitochondrial intermembrane space proteins as substrates of the MIA import pathway. Gabriel K, et al. J Mol Biol, 2007 Jan 19. PMID 17095012
  2. A discrete pathway for the transfer of intermembrane space proteins across the outer membrane of mitochondria. Gornicka A, et al. Mol Biol Cell, 2014 Dec 15. PMID 25318675, Free PMC Article
  3. Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol. Wrobel L, et al. Nature, 2015 Aug 27. PMID 26245374
  4. Systematic analysis of the twin cx(9)c protein family. Longen S, et al. J Mol Biol, 2009 Oct 23. PMID 19703468
  5. Yeast Nst1 is a novel component of P-bodies and is a specific suppressor of proteasome base assembly defects. Cheng CL, et al. Mol Biol Cell, 2021 Oct 1. PMID 34347506, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in aerobic respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Mix17p
NP_013715.1
  • Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    272193..272663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182498.1 → NP_013715.1  TPA: Mix17p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013715.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZH7, Q03667
    UniProtKB/TrEMBL
    A6ZM64, C8ZEK8, N1P5B3
    Conserved Domains (1) summary
    pfam06747
    Location:118 → 152
    CHCH; CHCH domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03667.1

Gene LinkOut

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