YAP1 DNA-binding transcription factor YAP1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: YAP1
Official Full Name: DNA-binding transcription factor YAP1
Primary source: SGD:S000004466
Locus tag: YML007W
See related: AllianceGenome:SGD:S000004466; FungiDB:YML007W; VEuPathDB:YML007W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PAR1; PDR4; SNQ3
Summary: Enables DNA-binding transcription factor activity. Involved in several processes, including regulation of endoplasmic reticulum unfolded protein response; response to heat; and response to singlet oxygen. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See YAP1 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (253848..255800)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Oxidative stress-induced YAP1 expression is regulated by NCE102, CDA2, and BCS1.
Title: Oxidative stress-induced YAP1 expression is regulated by NCE102, CDA2, and BCS1.
Manganese Stress Tolerance Depends on Yap1 and Stress-Activated MAP Kinases.
Title: Manganese Stress Tolerance Depends on Yap1 and Stress-Activated MAP Kinases.
Sequence-specific dynamics of DNA response elements and their flanking sites regulate the recognition by AP-1 transcription factors.
Title: Sequence-specific dynamics of DNA response elements and their flanking sites regulate the recognition by AP-1 transcription factors.
The mitochondrial iron exporter genes MMT1 and MMT2 in yeast are transcriptionally regulated by Aft1 and Yap1.
Title: The mitochondrial iron exporter genes MMT1 and MMT2 in yeast are transcriptionally regulated by Aft1 and Yap1.
Intrinsically Disordered Regions Direct Transcription Factor In Vivo Binding Specificity.
Title: Intrinsically Disordered Regions Direct Transcription Factor In Vivo Binding Specificity.
The deletion of transcription factors Yap1p or Skn7p was sufficient to disrupt the establishment of the second degradation phase of hydrogen peroxide, but not the initial phase.
Title: High-resolution kinetics and modeling of hydrogen peroxide degradation in live cells.
Yap1 and Skn7 genetically interact with Rad51 in response to oxidative stress and DNA double-strand break in Saccharomyces cerevisiae.
Title: Yap1 and Skn7 genetically interact with Rad51 in response to oxidative stress and DNA double-strand break in Saccharomyces cerevisiae.
Repression of SOD2 prevents ethanol-induced relocalization of yeast hydrogen peroxide-sensing transcription factor Yap1p, one of the key stress resistance proteins. Analysis of the ethanol sensitivities of the cells lacking Sod2p, Yap1p, or both indicated that the two proteins act in the same pathway.
Title: Mitochondrial Superoxide Dismutase and Yap1p Act as a Signaling Module Contributing to Ethanol Tolerance of the Yeast Saccharomyces cerevisiae.
Yap1p positively regulates ATG15 expression.
Title: ATG15 encodes a phospholipase and is transcriptionally regulated by YAP1 in Saccharomyces cerevisiae.
yap1 mutant is more sensitive to chemicals than wild-type cells and that the susceptible individuals carrying the YAP1-like gene defect may enhance risk to chemical exposure.
Title: Transcriptomic profiling of chemical exposure reveals roles of Yap1 in protecting yeast cells from oxidative and other types of stresses.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription cis-regulatory region binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	HMP more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of endoplasmic reticulum unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in response to arsenic-containing substance	HMP more info	PubMed
involved_in response to cadmium ion	IEA Inferred from Electronic Annotation more info
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to singlet oxygen	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA-binding transcription factor YAP1

NP_013707.1

Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; relative distribution to the nucleus increases upon DNA replication stress; YAP1 has a paralog, CAD1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

253848..255800

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182362.1 → NP_013707.1 TPA: DNA-binding transcription factor YAP1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013707.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZG8, P19880, P22631, Q06840

UniProtKB/TrEMBL

A6ZM56, N1NYK1

Conserved Domains (2) summary

cd14688
Location:65 → 126

bZIP_YAP; Basic leucine zipper (bZIP) domain of Yeast Activator Protein (YAP) and similar proteins: a DNA-binding and dimerization domain

pfam08601
Location:587 → 647

PAP1; Transcription factor PAP1