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CTK3 Ctk3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854928, updated on 3-Nov-2024

Summary

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Official Symbol
CTK3
Official Full Name
Ctk3p
Primary source
SGD:S000004580
Locus tag
YML112W
See related
AllianceGenome:SGD:S000004580; FungiDB:YML112W; VEuPathDB:YML112W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in positive regulation of DNA-templated transcription, elongation; positive regulation of transcription by RNA polymerase I; and positive regulation of translational fidelity. Located in nucleolus and nucleoplasm. Part of CTDK-1 complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CTK3 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (45063..45953)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Taf8p Neighboring gene Dat1p Neighboring gene ubiquitin-ubiquitin ligase BUL2 Neighboring gene 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression, purification and crystallization of the complex of RNA polymerase II carboxyl-terminal repeat domain kinase subunits CTK2-CTK3 from Saccharomyces cerevisiae. Zhu W, et al. Protein Expr Purif, 2019 Feb. PMID 30240633
  2. The yeast carboxyl-terminal repeat domain kinase CTDK-I is a divergent cyclin-cyclin-dependent kinase complex. Sterner DE, et al. Mol Cell Biol, 1995 Oct. PMID 7565723, Free PMC Article
  3. Modulation of RNA polymerase II elongation efficiency by C-terminal heptapeptide repeat domain kinase I. Lee JM, et al. J Biol Chem, 1997 Apr 25. PMID 9110987
  4. Genetics of transcriptional regulation in yeast: connections to the RNA polymerase II CTD. Carlson M. Annu Rev Cell Dev Biol, 1997. PMID 9442866
  5. Activation of the cyclin-dependent kinase CTDK-I requires the heterodimerization of two unstable subunits. Hautbergue G, et al. J Biol Chem, 2001 Mar 16. PMID 11118453

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structure and activation mechanism of the yeast RNA Pol II CTD kinase CTDK-1 complex.
    Title: Structure and activation mechanism of the yeast RNA Pol II CTD kinase CTDK-1 complex.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription, elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription, elongation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription, elongation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase I IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of translational fidelity IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of CTDK-1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CTDK-1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of CTDK-1 complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ctk3p
NP_013595.1
  • Gamma subunit of C-terminal domain kinase I; CTDK-I phosphorylates RNA polymerase II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and also phosphorylates ribosomal protein Rps2p to increase translational fidelity; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    45063..45953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182474.1 → NP_013595.1  TPA: Ctk3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013595.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0H2, P46963, Q6LBS6
    UniProtKB/TrEMBL
    A6ZLV2, B5VP19, N1NYQ0
    Conserved Domains (1) summary
    pfam12350
    Location:225 → 284
    CTK3_C; CTD kinase subunit gamma CTK3 C-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46963.2

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