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ERG13 hydroxymethylglutaryl-CoA synthase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854913, updated on 2-Nov-2024

Summary

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Official Symbol
ERG13
Official Full Name
hydroxymethylglutaryl-CoA synthase
Primary source
SGD:S000004595
Locus tag
YML126C
See related
AllianceGenome:SGD:S000004595; FungiDB:YML126C; VEuPathDB:YML126C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HMGS
Summary
Enables hydroxymethylglutaryl-CoA synthase activity. Involved in ergosterol biosynthetic process. Located in nucleus. Human ortholog(s) of this gene implicated in HMG-CoA synthase 2 deficiency. Orthologous to several human genes including HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ERG13 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (19060..20535, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Msc1p Neighboring gene Rsc9p Neighboring gene cytochrome-b5 reductase Neighboring gene alpha-tubulin TUB3 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The biosynthesis of beta-hydroxy-beta-methylglutaryl coenzyme A in yeast. IV. The origin of the thioester bond of beta-hydroxy-beta-methylglutaryl coenzyme A. Stewart PR, et al. J Biol Chem, 1966 Mar 10. PMID 5933878
  2. Isolation and characterization of yeast mutants blocked in mevalonic acid formation. Servouse M, et al. Biochem Biophys Res Commun, 1984 Sep 17. PMID 6148937
  3. Engineering a functional 1-deoxy-D-xylulose 5-phosphate (DXP) pathway in Saccharomyces cerevisiae. Kirby J, et al. Metab Eng, 2016 Nov. PMID 27989805, Free PMC Article
  4. Dolichol biosynthesis in the yeast Saccharomyces cerevisiae: an insight into the regulatory role of farnesyl diphosphate synthase. Grabińska K, et al. FEMS Yeast Res, 2002 Aug. PMID 12702274
  5. The biosynthesis of beta-hydroxy-beta-methylglutaryl coenzyme A in yeast. I. Identification and purification of the hydroxymethylglutaryl coenzymecondensing enzyme. FERGUSON JJ Jr, et al. J Biol Chem, 1959 May. PMID 13654321

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydroxymethylglutaryl-CoA synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydroxymethylglutaryl-CoA synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydroxymethylglutaryl-CoA synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acetyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acetyl-CoA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ergosterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ergosterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
hydroxymethylglutaryl-CoA synthase
NP_013580.1
  • 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase; catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    19060..20535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182489.1 → NP_013580.1  TPA: hydroxymethylglutaryl-CoA synthase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013580.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0F9, P54839
    UniProtKB/TrEMBL
    A6ZLT9, B3LLD4, C7GVA7, C8ZE76, G2WJT1, N1NXW8
    Conserved Domains (1) summary
    TIGR01833
    Location:45 → 490
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54839.1

Gene LinkOut

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