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GIM5 Gim5p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854879, updated on 3-Nov-2024

Summary

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Official Symbol
GIM5
Official Full Name
Gim5p
Primary source
SGD:S000004559
Locus tag
YML094W
See related
AllianceGenome:SGD:S000004559; FungiDB:YML094W; VEuPathDB:YML094W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PFD5
Summary
Enables tubulin binding activity. Involved in positive regulation of transcription elongation by RNA polymerase II and tubulin complex assembly. Located in cytoplasm. Part of prefoldin complex. Orthologous to human PFDN5 (prefoldin subunit 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See GIM5 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
2
Sequence:
Chromosome: XIII; NC_001145.3 (82275..82849)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene guanine nucleotide exchange factor VPS9 Neighboring gene putative asparagine synthase Neighboring gene DNA repair protein RAD10 Neighboring gene Utp14p Neighboring gene proteasome core particle subunit alpha 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hsp70-associated chaperones have a critical role in buffering protein production costs. Farkas Z, et al. Elife, 2018 Jan 29. PMID 29377792, Free PMC Article
  2. Absence of Gim proteins, but not GimC complex, alters stress-induced transcription. Amorim AF, et al. Biochim Biophys Acta Gene Regul Mech, 2017 Jul. PMID 28457997
  3. The yeast ubiquitin protease, Ubp3p, promotes protein stability. Brew CT, et al. Genetics, 2002 Nov. PMID 12454057, Free PMC Article
  4. Yeast Uri1p promotes translation initiation and may provide a link to cotranslational quality control. Deplazes A, et al. EMBO J, 2009 May 20. PMID 19387492, Free PMC Article
  5. A targeted analysis of cellular chaperones reveals contrasting roles for heat shock protein 70 in flock house virus RNA replication. Weeks SA, et al. J Virol, 2010 Jan. PMID 19828623, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase I assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA polymerase II core complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA polymerase III assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription elongation by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in tubulin complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of prefoldin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of prefoldin complex IEA
Inferred from Electronic Annotation
more info
  
part_of prefoldin complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
Gim5p
NP_013616.1
  • Subunit of the heterohexameric cochaperone prefoldin complex; prefoldin binds specifically to cytosolic chaperonin and transfers target proteins to it; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    82275..82849
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182453.1 → NP_013616.1  TPA: Gim5p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013616.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0J1, Q04493
    UniProtKB/TrEMBL
    A6ZLX3, B3LLG4, C8ZEB1, G2WJW3, N1P5X4
    Conserved Domains (1) summary
    COG1730
    Location:6 → 149
    GIM5; Prefoldin subunit 5 [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04493.1

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