U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MDM1 Mdm1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854867, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
MDM1
Official Full Name
Mdm1p
Primary source
SGD:S000004572
Locus tag
YML104C
See related
AllianceGenome:SGD:S000004572; FungiDB:YML104C; VEuPathDB:YML104C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phosphatidylinositol-3-phosphate binding activity. Involved in mitochondrion inheritance; piecemeal microautophagy of the nucleus; and vacuole-ER tethering. Located in cell periphery and fungal-type vacuole. Is active in nucleus-vacuole junction. Used to study autosomal recessive spinocerebellar ataxia 20. Orthologous to human SNX13 (sorting nexin 13) and SNX25 (sorting nexin 25). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See MDM1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (58939..62322, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene orotate phosphoribosyltransferase URA5 Neighboring gene RNA-binding signal recognition particle subunit SEC65 Neighboring gene Nup188p Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Nuclear and mitochondrial inheritance in yeast depends on novel cytoplasmic structures defined by the MDM1 protein. McConnell SJ, et al. J Cell Biol, 1992 Jul. PMID 1378448, Free PMC Article
  2. Intermediate filament formation by a yeast protein essential for organelle inheritance. McConnell SJ, et al. Science, 1993 Apr 30. PMID 8480179
  3. Mutational analysis of Mdm1p function in nuclear and mitochondrial inheritance. Fisk HA, et al. J Cell Biol, 1997 Aug 11. PMID 9245780, Free PMC Article
  4. Mdm1/Snx13 is a novel ER-endolysosomal interorganelle tethering protein. Henne WM, et al. J Cell Biol, 2015 Aug 17. PMID 26283797, Free PMC Article
  5. Temperature-sensitive yeast mutants defective in mitochondrial inheritance. McConnell SJ, et al. J Cell Biol, 1990 Sep. PMID 2202739, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sorting nexin Mdm1/SNX14 regulates nucleolar dynamics at the NVJ after TORC1 inactivation.
    Title: Sorting nexin Mdm1/SNX14 regulates nucleolar dynamics at the NVJ after TORC1 inactivation.
  2. Mdm1 coordinates fatty acid activation adjacent to the vacuole to promote lipid droplet production in response to stress, thus maintaining endoplasmic reticulum homeostasis.
    Title: Mdm1 maintains endoplasmic reticulum homeostasis by spatially regulating lipid droplet biogenesis.
  3. Mdm1 is endoplasmic reticulum anchored and contacts the vacuole surface in trans via its lipid-binding PX domain.
    Title: Mdm1/Snx13 is a novel ER-endolysosomal interorganelle tethering protein.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrion inheritance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in piecemeal microautophagy of the nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vacuole-ER tethering IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole HDA PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus-vacuole junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus-vacuole junction IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Mdm1p
NP_013603.1
  • PtdIns-3-P binding protein that tethers the ER to vacuoles at NVJs; anchored in the ER membrane at nucleus-vacuole junctions and binds phosphatidylinositol 3-phosphate (PtdIns-3-P) in the vacuolar membrane via its Phox homology (PX) domain; expressed predominantly in late G1 to early S phase of the cell cycle; mutation affects nuclear and mitochondrial transmission to daughter buds; similar to 4 human genes, one of which (SNX14) is associated with neurological disease

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    58939..62322 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182466.1 → NP_013603.1  TPA: Mdm1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013603.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0I0, Q01846, Q04196
    UniProtKB/TrEMBL
    G2WJV2
    Conserved Domains (4) summary
    cd06876
    Location:763 → 900
    PX_MDM1p; The phosphoinositide binding Phox Homology domain of yeast MDM1p
    smart00313
    Location:85 → 276
    PXA; Domain associated with PX domains
    pfam08628
    Location:993 → 1106
    Nexin_C; Sorting nexin C terminal
    cl02565
    Location:462 → 567
    RGS; Regulator of G protein signaling (RGS) domain superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01846.3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools