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YPS6 aspartyl protease [ Saccharomyces cerevisiae S288C ]

Gene ID: 854857, updated on 2-Nov-2024

Summary

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Official Symbol
YPS6
Official Full Name
aspartyl protease
Primary source
SGD:S000001478
Locus tag
YIR039C
See related
AllianceGenome:SGD:S000001478; FungiDB:YIR039C; VEuPathDB:YIR039C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable aspartic-type endopeptidase activity. Involved in fungal-type cell wall organization. Located in fungal-type cell wall. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See YPS6 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (430498..432111, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene peroxiredoxin HYR1 Neighboring gene bifunctional glutathione transferase/peroxidase Neighboring gene seripauperin PAU15 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterization of Saccharomyces cerevisiae yapsin 3, a new member of the yapsin family of aspartic proteases encoded by the YPS3 gene. Olsen V, et al. Biochem J, 1999 Apr 15. PMID 10191273, Free PMC Article
  2. Multiple-yapsin-deficient mutant strains for high-level production of intact recombinant proteins in Saccharomyces cerevisiae. Cho EY, et al. J Biotechnol, 2010 Aug 20. PMID 20599573
  3. Proteolytic processing of the Saccharomyces cerevisiae cell wall protein Scw4 regulates its activity and influences its covalent binding to glucan. Grbavac A, et al. Biochim Biophys Acta Mol Cell Res, 2017 Mar. PMID 27965112
  4. Yapsins are a family of aspartyl proteases required for cell wall integrity in Saccharomyces cerevisiae. Krysan DJ, et al. Eukaryot Cell, 2005 Aug. PMID 16087741, Free PMC Article
  5. Genomic signatures of adaptation to wine biological ageing conditions in biofilm-forming flor yeasts. Coi AL, et al. Mol Ecol, 2017 Apr. PMID 28192619

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables aspartic-type endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in fungal-type cell wall organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fungal-type cell wall organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in fungal-type cell wall IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type cell wall IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
aspartyl protease
NP_012305.3
  • Putative GPI-anchored aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    430498..432111 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179561.3 → NP_012305.3  TPA: aspartyl protease [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012305.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVX0, E9PAD7, P40583
    UniProtKB/TrEMBL
    G2WFW7
    Conserved Domains (1) summary
    cd05474
    Location:65 → 428
    SAP_like; SAPs, pepsin-like proteinases secreted from pathogens to degrade host proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40583.1

Gene LinkOut

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