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YVH1 tyrosine protein phosphatase YVH1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854844, updated on 2-Nov-2024

Summary

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Official Symbol
YVH1
Official Full Name
tyrosine protein phosphatase YVH1
Primary source
SGD:S000001465
Locus tag
YIR026C
See related
AllianceGenome:SGD:S000001465; FungiDB:YIR026C; VEuPathDB:YIR026C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables preribosome binding activity and protein tyrosine phosphatase activity. Involved in several processes, including ascospore wall assembly; positive regulation of autophagosome assembly; and ribosome biogenesis. Located in cytoplasm and nucleus. Orthologous to human DUSP12 (dual specificity phosphatase 12). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See YVH1 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (404873..405967, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Ina22p Neighboring gene Mnd2p Neighboring gene allantoinase Neighboring gene allantoin permease

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A yeast protein phosphatase related to the vaccinia virus VH1 phosphatase is induced by nitrogen starvation. Guan K, et al. Proc Natl Acad Sci U S A, 1992 Dec 15. PMID 1334559, Free PMC Article
  2. Yvh1 protein phosphatase is required for pre-autophagosomal structure formation after TORC1 inactivation. Yeasmin AM, et al. Biosci Biotechnol Biochem, 2015. PMID 26125457
  3. The Pyst2-L phosphatase is involved in cell-crowding. Levy-Nissenbaum O, et al. Immunol Lett, 2006 Apr 15. PMID 16386315
  4. The dual-specificity protein phosphatase Yvh1p regulates sporulation, growth, and glycogen accumulation independently of catalytic activity in Saccharomyces cerevisiae via the cyclic AMP-dependent protein kinase cascade. Beeser AE, et al. J Bacteriol, 2000 Jun. PMID 10852885, Free PMC Article
  5. Dual-specificity protein phosphatase Yvh1p, which is required for vegetative growth and sporulation, interacts with yeast pescadillo homolog in Saccharomyces cerevisiae. Sakumoto N, et al. Biochem Biophys Res Commun, 2001 Nov 30. PMID 11716519

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Yvh1 phosphatase is critical for PAS formation
    Title: Yvh1 protein phosphatase is required for pre-autophagosomal structure formation after TORC1 inactivation.
  2. the interaction between Mrt4 and Yvh1 is also essential for normal glycogen accumulation and mRNA decay as well as the induction of sporulation genes
    Title: Genetic interactions of ribosome maturation factors Yvh1 and Mrt4 influence mRNA decay, glycogen accumulation, and the expression of early meiotic genes in Saccharomyces cerevisiae.
  3. Yvh1 is required for a late maturation step in the 60S biogenesis pathway.
    Title: Yvh1 is required for a late maturation step in the 60S biogenesis pathway.
  4. Ribosome stalk assembly requires the dual-specificity phosphatase Yvh1 for the exchange of Mrt4 with P0.
    Title: Ribosome stalk assembly requires the dual-specificity phosphatase Yvh1 for the exchange of Mrt4 with P0.
  5. Changes in ribosome biogenesis caused by loss of Yvh1 or specific ribosomal proteins have effects on the plasma membrane, perhaps by producing specific translational changes.
    Title: A mutant plasma membrane protein is stabilized upon loss of Yvh1, a novel ribosome assembly factor.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables preribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine/serine/threonine phosphatase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
involved_in ascospore wall assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ascospore wall assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to nitrogen starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal large subunit assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ribosomal large subunit assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit export from nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ribosomal large subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic stress granule HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tyrosine protein phosphatase YVH1
NP_012292.3
  • Dual specificity protein phosphatase; regulates growth, sporulation, and glycogen accumulation in a cAMP-dependent protein kinase cascade dependent manner; mutants are defective in 60S ribosome assembly; positively regulates pre-autophagosomal structure (PAS) formation upon nitrogen starvation or rapamycin treatment

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    404873..405967 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179548.3 → NP_012292.3  TPA: tyrosine protein phosphatase YVH1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012292.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVV7, Q02256
    UniProtKB/TrEMBL
    A6ZVU6, C7GLT0, G2WFV4, N1P983
    Conserved Domains (1) summary
    cd14518
    Location:12 → 173
    DSP_fungal_YVH1; dual specificity phosphatase domain of fungal YVH1-like dual specificity protein phosphatase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02256.1

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