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STS1 Sts1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854828, updated on 2-Nov-2024

Summary

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Official Symbol
STS1
Official Full Name
Sts1p
Primary source
SGD:S000001450
Locus tag
YIR011C
See related
AllianceGenome:SGD:S000001450; FungiDB:YIR011C; VEuPathDB:YIR011C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DBF8; SSM5
Summary
Enables proteasome binding activity. Involved in chromosome segregation; nuclear protein quality control by the ubiquitin-proteasome system; and proteasome localization. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See STS1 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (377287..378246, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene U2 snRNP complex subunit MSL1 Neighboring gene MIND complex subunit DSN1 Neighboring gene Sqt1p Neighboring gene Gat4p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DBF8, an essential gene required for efficient chromosome segregation in Saccharomyces cerevisiae. Houman F, et al. Mol Cell Biol, 1994 Sep. PMID 8065366, Free PMC Article
  2. Multicopy STS1 restores both protein transport and ribosomal RNA stability in a new yeast sec23 mutant allele. Liang S, et al. Eur J Cell Biol, 1993 Dec. PMID 7925484
  3. Yeast 26S proteasome nuclear import is coupled to nucleus-specific degradation of the karyopherin adaptor protein Sts1. Breckel CA, et al. Sci Rep, 2024 Jan 24. PMID 38267508, Free PMC Article
  4. Yeast importin-α (Srp1) performs distinct roles in the import of nuclear proteins and in targeting proteasomes to the nucleus. Chen L, et al. J Biol Chem, 2014 Nov 14. PMID 25274630, Free PMC Article
  5. Mutations in STS1 suppress the defect in 3' mRNA processing caused by the rna15-2 mutation in Saccharomyces cerevisiae. Amrani N, et al. Mol Gen Genet, 1996 Oct 16. PMID 8914516

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Yeast 26S proteasome nuclear import is coupled to nucleus-specific degradation of the karyopherin adaptor protein Sts1.
    Title: Yeast 26S proteasome nuclear import is coupled to nucleus-specific degradation of the karyopherin adaptor protein Sts1.
  2. This study unveils a previously unknown role for Srp1 and Sts1 in cotranslational protein degradation and suggests a novel model whereby Srp1 and Sts1 cooperate to couple proteasomes to ribosome-bound nascent polypeptides.
    Title: Nuclear import factor Srp1 and its associated protein Sts1 couple ribosome-bound nascent polypeptides to proteasomes for cotranslational degradation.
  3. Sts1 plays a key role in targeting proteasomes to the nucleus.
    Title: Sts1 plays a key role in targeting proteasomes to the nucleus.
  4. Sts1 is a new regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates.
    Title: Sts1 can overcome the loss of Rad23 and Rpn10 and represents a novel regulator of the ubiquitin/proteasome pathway.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables proteasome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proteasome binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear protein quality control by the ubiquitin-proteasome system IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear protein quality control by the ubiquitin-proteasome system IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear protein quality control by the ubiquitin-proteasome system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome localization IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with nuclear membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Sts1p
NP_012276.1
  • Karyopherin adaptor required for nuclear translocation of the proteasome; mediates interaction between nuclear import factor Srp1p and the proteasome; nuclear import of the 26S proteasome is coupled to RanGTP-initiated, ubiquitin-independent proteasomal degradation of Sts1p; Sts1p and Srp1p couple proteasomes to nascent polypeptides emerging from the ribosome for cotranslational degradation; role in ubiquitin-mediated protein degradation; contains a bipartite nuclear localization sequence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    377287..378246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179533.1 → NP_012276.1  TPA: Sts1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012276.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B3LTJ8, C7GJG1, C8ZAR0, D6VVU1, E7KDX7, E7LVV3, E7QG80, P35188, P38637
    UniProtKB/TrEMBL
    G2WGF7, N1P977
    Conserved Domains (1) summary
    pfam08559
    Location:79 → 274
    Cut8; nuclear proteasome tether protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38637.1

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