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AIM21 Aim21p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854819, updated on 2-Nov-2024

Summary

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Official Symbol
AIM21
Official Full Name
Aim21p
Primary source
SGD:S000001442
Locus tag
YIR003W
See related
AllianceGenome:SGD:S000001442; FungiDB:YIR003W; VEuPathDB:YIR003W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to actin filament binding activity. Involved in mitochondrion migration along actin filament and negative regulation of actin filament polymerization. Located in actin cortical patch. Part of Aim21-Tda2 complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See AIM21 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (360885..362924)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Sgn1p Neighboring gene 3'-5' DNA helicase Neighboring gene Djp1p Neighboring gene U2 snRNP complex subunit IST3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The dynein light chain protein Tda2 functions as a dimerization engine to regulate actin capping protein during endocytosis. Lamb AK, et al. Mol Biol Cell, 2021 Aug 1. PMID 34081539, Free PMC Article
  2. Novel function of a dynein light chain in actin assembly during clathrin-mediated endocytosis. Farrell KB, et al. J Cell Biol, 2017 Aug 7. PMID 28706108, Free PMC Article
  3. A protein polymerization cascade mediates toxicity of non-pathological human huntingtin in yeast. Serpionov GV, et al. Sci Rep, 2015 Dec 17. PMID 26673834, Free PMC Article
  4. Unusual binding properties of the SH3 domain of the yeast actin-binding protein Abp1: structural and functional analysis. Fazi B, et al. J Biol Chem, 2002 Feb 15. PMID 11668184
  5. Yeast Aim21/Tda2 both regulates free actin by reducing barbed end assembly and forms a complex with Cap1/Cap2 to balance actin assembly between patches and cables. Shin M, et al. Mol Biol Cell, 2018 Apr 15. PMID 29467252, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mechanism of actin capping protein recruitment and turnover during clathrin-mediated endocytosis.
    Title: Mechanism of actin capping protein recruitment and turnover during clathrin-mediated endocytosis.
  2. The dynein light chain protein Tda2 functions as a dimerization engine to regulate actin capping protein during endocytosis.
    Title: The dynein light chain protein Tda2 functions as a dimerization engine to regulate actin capping protein during endocytosis.
  3. Loss of the cortical patch protein Aim21 suppresses the growth defect of tpm1 cells. Aim21 regulates the abundance of actin in cortical patches and this regulation is necessary for efficient endocytosis.
    Title: Yeast Aim21/Tda2 both regulates free actin by reducing barbed end assembly and forms a complex with Cap1/Cap2 to balance actin assembly between patches and cables.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrion migration along actin filament IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of Aim21-Tda2 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in actin cortical patch IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actin cortical patch IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in mating projection tip HDA PubMed 

General protein information

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Preferred Names
Aim21p
NP_012268.3
  • Subunit of a complex that associates with actin filaments; forms a complex with Tda2p that inhibits barbed end F-actin assembly; elevates actin monomer pools to increase endocytotic efficiency and to regulate the distribution of actin between cables and patches; Aim21p/Tda2p forms a larger complex with actin capping proteins Cap1p and Cap2p; involved in mitochondrial migration along actin filaments; recruited to cortical actin patches by SH3 domain-containing proteins Bbc1p and Abp1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    360885..362924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179525.3 → NP_012268.3  TPA: Aim21p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012268.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C8ZAQ2, D6VVT3, P40563
    UniProtKB/TrEMBL
    N1P487
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40563.1

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