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VID28 glucose-induced degradation complex subunit VID28 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854795, updated on 18-Sep-2024

Summary

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Official Symbol
VID28
Official Full Name
glucose-induced degradation complex subunit VID28
Primary source
SGD:S000001279
Locus tag
YIL017C
See related
AllianceGenome:SGD:S000001279; FungiDB:YIL017C; VEuPathDB:YIL017C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GID5; YIL017W
Summary
Involved in negative regulation of gluconeogenesis; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein catabolic process in the vacuole. Located in cytoplasm and nucleus. Part of GID complex. Orthologous to human ARMC8 (armadillo repeat containing 8). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See VID28 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (318200..320965, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Faf1p Neighboring gene ribosomal 60S subunit protein L2B Neighboring gene Snl1p Neighboring gene aspartyl protease BAR1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Vid28 protein is required for the association of vacuole import and degradation (Vid) vesicles with actin patches and the retention of Vid vesicle proteins in the intracellular fraction. Giardina BJ, et al. J Biol Chem, 2013 Apr 26. PMID 23393132, Free PMC Article
  2. Intracellular vesicle clusters are organelles that synthesize extracellular vesicle-associated cargo proteins in yeast. Winters CM, et al. J Biol Chem, 2020 Feb 28. PMID 31974164, Free PMC Article
  3. Regulation of the Gid ubiquitin ligase recognition subunit Gid4. Menssen R, et al. FEBS Lett, 2018 Oct. PMID 30136317
  4. Exploring the topology of the Gid complex, the E3 ubiquitin ligase involved in catabolite-induced degradation of gluconeogenic enzymes. Menssen R, et al. J Biol Chem, 2012 Jul 20. PMID 22645139, Free PMC Article
  5. Cryo-EM structures of Gid12-bound GID E3 reveal steric blockade as a mechanism inhibiting substrate ubiquitylation. Qiao S, et al. Nat Commun, 2022 Jun 1. PMID 35650207, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Vid28 protein is required for the association of vacuole import and degradation (Vid) vesicles with actin patches and the retention of Vid vesicle proteins in the intracellular fraction.
    Title: Vid28 protein is required for the association of vacuole import and degradation (Vid) vesicles with actin patches and the retention of Vid vesicle proteins in the intracellular fraction.
  2. Three members of the VID and GID gene families, VID30/GID1, GID2, and VID28/GID5 are needed for the rapamycin or nitrogen starvation-induced degradation of the high-affinity hexose transporter Hxt7p is shown here.
    Title: Components of the Vid30c are needed for the rapamycin-induced degradation of the high-affinity hexose transporter Hxt7p in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in ascospore formation HMP PubMed 
involved_in negative regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein catabolic process in the vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of GID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GID complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glucose-induced degradation complex subunit VID28
NP_012247.3
  • GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    318200..320965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179367.3 → NP_012247.3  TPA: glucose-induced degradation complex subunit VID28 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012247.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVR2, P40547
    UniProtKB/TrEMBL
    B3LTM5
    Conserved Domains (2) summary
    COG5369
    Location:1 → 918
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:586 → 610
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40547.1

Gene LinkOut

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