CAP2 F-actin-capping protein subunit beta [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Official Symbol: CAP2
Official Full Name: F-actin-capping protein subunit beta
Primary source: SGD:S000001296
Locus tag: YIL034C
See related: AllianceGenome:SGD:S000001296; FungiDB:YIL034C; VEuPathDB:YIL034C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables actin filament binding activity. Involved in barbed-end actin filament capping and filamentous growth. Located in cellular bud tip; cortical actin cytoskeleton; and incipient cellular bud site. Part of F-actin capping protein complex. Orthologous to human CAPZB (capping actin protein of muscle Z-line subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See CAP2 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (289226..290089, complement)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A subunit of actin capping protein, Cap2p, interacted with the cytoplasmic domain of Msb2p.
Title: Proteins That Interact with the Mucin-Type Glycoprotein Msb2p Include a Regulator of the Actin Cytoskeleton.
a novel model for how sequential interactions between actin monomers, twinfilin, CP, and actin filaments promote cytoskeletal dynamics
Title: Biological role and structural mechanism of twinfilin-capping protein interaction.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in actin filament capping	IEA Inferred from Electronic Annotation more info
involved_in barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in barbed-end actin filament capping	IDA Inferred from Direct Assay more info	PubMed
involved_in barbed-end actin filament capping	IEA Inferred from Electronic Annotation more info
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in filamentous growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of F-actin capping protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of F-actin capping protein complex	IDA Inferred from Direct Assay more info	PubMed
part_of F-actin capping protein complex	IEA Inferred from Electronic Annotation more info
part_of F-actin capping protein complex	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in actin cortical patch	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cortical patch	IDA Inferred from Direct Assay more info	PubMed
located_in actin cortical patch	IEA Inferred from Electronic Annotation more info
located_in cellular bud	IEA Inferred from Electronic Annotation more info
located_in cellular bud neck contractile ring	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud tip	HDA more info	PubMed
located_in cellular bud tip	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud tip	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in incipient cellular bud site	IDA Inferred from Direct Assay more info	PubMed
located_in mating projection tip	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: F-actin-capping protein subunit beta

NP_012230.3

Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches and the cytokinetic contractile ring; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

289226..290089 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179384.3 → NP_012230.3 TPA: F-actin-capping protein subunit beta [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012230.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVP8, P13517, Q07082

UniProtKB/TrEMBL

A6ZVN5, B3LTP0, C7GVW2, C8ZAL2, N1P455

Conserved Domains (1) summary

pfam01115
Location:11 → 256

F_actin_cap_B; F-actin capping protein, beta subunit