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THS1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854732, updated on 11-Sep-2024

Summary

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Official Symbol
THS1
Primary source
SGD:S000001340
Locus tag
YIL078W
See related
AllianceGenome:SGD:S000001340; FungiDB:YIL078W; VEuPathDB:YIL078W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables threonine-tRNA ligase activity. Involved in threonyl-tRNA aminoacylation. Located in cytoplasm. Used to study amino acid metabolic disorder. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 21 and nonphotosensitive trichothiodystrophy 7. Orthologous to several human genes including TARS3 (threonyl-tRNA synthetase 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (212499..214703)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene tRNA-Ile Neighboring gene TRAMP complex RNA-binding subunit Neighboring gene Rci37p Neighboring gene coatomer subunit epsilon

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of lethal mutations in yeast threonyl-tRNA synthetase revealing critical residues in its human homolog. Ruan ZR, et al. J Biol Chem, 2015 Jan 16. PMID 25416776, Free PMC Article
  2. Translational fidelity maintenance preventing Ser mis-incorporation at Thr codon in protein from eukaryote. Zhou XL, et al. Nucleic Acids Res, 2013 Jan 7. PMID 23093606, Free PMC Article
  3. Threonyl-tRNA synthetase from yeast. Discrimination of 19 amino acids in aminoacylation of tRNA(Thr)-C-C-A and tRNA(Thr)-C-C-A(2'NH2). Freist W, et al. Eur J Biochem, 1994 Mar 15. PMID 8143729
  4. The Cdc48-20S proteasome degrades a class of endogenous proteins in a ubiquitin-independent manner. Islam MT, et al. Biochem Biophys Res Commun, 2020 Mar 19. PMID 31954512
  5. Cloning and characterization of the gene for the yeast cytoplasmic threonyl-tRNA synthetase. Pape LK, et al. Nucleic Acids Res, 1985 Sep 11. PMID 2995918, Free PMC Article

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of critical residues in ThrS based on lethal mutations in yeast
    Title: Identification of lethal mutations in yeast threonyl-tRNA synthetase revealing critical residues in its human homolog.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity, acting on a tRNA IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables threonine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables threonine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables threonine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
involved_in threonyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in threonyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in threonyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
threonine--tRNA ligase THS1
NP_116578.3
  • Threonyl-tRNA synthetase involved in tRNA aminoacylation; mRNA binding protein that preferentially binds to the mRNA of RNAPI subunits and DNA binding proteins; binds to an anticodon stem loop-like structure in RPC10 and impacts its translation; cytoplasmic protein; human homolog TARS can complement a yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    212499..214703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179428.3 → NP_116578.3  TPA: threonine--tRNA ligase THS1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116578.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVK6, P04801
    UniProtKB/TrEMBL
    A6ZVJ5
    Conserved Domains (1) summary
    PLN02908
    Location:46 → 728
    PLN02908; threonyl-tRNA synthetase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04801.2

Gene LinkOut

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