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SIM1 putative glucosidase SIM1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854683, updated on 2-Nov-2024

Summary

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Official Symbol
SIM1
Official Full Name
putative glucosidase SIM1
Primary source
SGD:S000001385
Locus tag
YIL123W
See related
AllianceGenome:SGD:S000001385; FungiDB:YIL123W; VEuPathDB:YIL123W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable hydrolase activity, acting on glycosyl bonds. Involved in fungal-type cell wall organization. Located in fungal-type cell wall. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SIM1 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (128151..129581)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene alpha-ketoglutarate dehydrogenase KGD1 Neighboring gene acylglycerone-phosphate reductase Neighboring gene Pog1p Neighboring gene cation transporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The SUN family of Saccharomyces cerevisiae: the double knock-out of UTH1 and SIM1 promotes defects in nucleus migration and increased drug sensitivity. Mouassite M, et al. FEMS Microbiol Lett, 2000 Jan 1. PMID 10612745
  2. In Vivo-In Vitro Comparative Toxicology of Cadmium Sulphide Quantum Dots in the Model Organism Saccharomyces cerevisiae. Pagano L, et al. Nanomaterials (Basel), 2019 Apr 2. PMID 30986968, Free PMC Article
  3. Dual cell wall/mitochondria localization of the 'SUN' family proteins. Velours G, et al. FEMS Microbiol Lett, 2002 Feb 5. PMID 11958935
  4. SUN family proteins Sun4p, Uth1p and Sim1p are secreted from Saccharomyces cerevisiae and produced dependently on oxygen level. Kuznetsov E, et al. PLoS One, 2013. PMID 24040106, Free PMC Article
  5. Pag1p, a novel protein associated with protein kinase Cbk1p, is required for cell morphogenesis and proliferation in Saccharomyces cerevisiae. Du LL, et al. Mol Biol Cell, 2002 Feb. PMID 11854408, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ssd1 regulates translation of its target message primarily through UTRs and the SIM1 message through multiple potential points of interaction, permitting fine translational control in various contexts.
    Title: Cell morphogenesis proteins are translationally controlled through UTRs by the Ndr/LATS target Ssd1.
  2. SUN family proteins Sun4p, Uth1p and Sim1p are secreted from Saccharomyces cerevisiae and produced dependently on oxygen level.
    Title: SUN family proteins Sun4p, Uth1p and Sim1p are secreted from Saccharomyces cerevisiae and produced dependently on oxygen level.
  3. TORC2 has been shown previously to negatively regulate calcineurin in part by phosphorylating two related proteins, Slm1 and Slm2, which associate with the PM via plextrin homology domains
    Title: Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in fungal-type cell wall organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fungal-type cell wall organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in polysaccharide catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in fungal-type cell wall IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type cell wall IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
putative glucosidase SIM1
NP_012143.2
  • Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p); may participate in DNA replication; promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated; SIM1 has a paralog, SUN4, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    128151..129581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179471.2 → NP_012143.2  TPA: putative glucosidase SIM1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012143.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A2TBN1, D6VVG4, P40472, Q45U06, Q870H1
    UniProtKB/TrEMBL
    B3LTX0, N1P9A4
    Conserved Domains (1) summary
    pfam03856
    Location:221 → 462
    SUN; Beta-glucosidase (SUN family)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40472.2

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