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VHS2 Vhs2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854671, updated on 2-Nov-2024

Summary

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Official Symbol
VHS2
Official Full Name
Vhs2p
Primary source
SGD:S000001397
Locus tag
YIL135C
See related
AllianceGenome:SGD:S000001397; FungiDB:YIL135C; VEuPathDB:YIL135C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in cellular bud neck septin ring organization; cellular response to heat; and establishment or maintenance of actin cytoskeleton polarity. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See VHS2 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (95065..96375, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Tma108p Neighboring gene Om45p Neighboring gene uncharacterized protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Vhs2 is a novel regulator of septin dynamics in budding yeast. Cassani C, et al. Cell Cycle, 2014. PMID 24646733, Free PMC Article
  2. Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeletal protein function and cell cycle progression. Stirling PC, et al. Mol Biol Cell, 2007 Jun. PMID 17429077, Free PMC Article
  3. Identification of multicopy suppressors of cell cycle arrest at the G1-S transition in Saccharomyces cerevisiae. Muñoz I, et al. Yeast, 2003 Jan 30. PMID 12518319
  4. Four novel suppressors of gic1 gic2 and their roles in cytokinesis and polarized cell growth in Saccharomyces cerevisiae. Gandhi M, et al. Genetics, 2006 Oct. PMID 16816427, Free PMC Article
  5. Substrate specificity analysis of protein kinase complex Dbf2-Mob1 by peptide library and proteome array screening. Mah AS, et al. BMC Biochem, 2005 Oct 21. PMID 16242037, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cellular bud neck septin ring organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular bud neck septin ring organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to heat IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in establishment or maintenance of actin cytoskeleton polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Vhs2p
NP_012131.1
  • Regulator of septin dynamics; involved in the regulation of septin dynamics at bud neck after mitotic entry, likely by stabilizing septin structure; regulated at post-translational level by cell cycle dependent phosphorylation; likely phosphorylated by Cdc28p and dephosphorylated by Cdc14p before cytokinesis; high-copy suppressor of synthetic lethality of sis2 sit4 double mutant; VHS2 has a paralog, MLF3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    95065..96375 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179483.1 → NP_012131.1  TPA: Vhs2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012131.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVF1, P40463
    UniProtKB/TrEMBL
    A6ZVE0, B3LTY3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40463.1

Gene LinkOut

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