U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TPM2 tropomyosin TPM2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854668, updated on 3-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
TPM2
Official Full Name
tropomyosin TPM2
Primary source
SGD:S000001400
Locus tag
YIL138C
See related
AllianceGenome:SGD:S000001400; FungiDB:YIL138C; VEuPathDB:YIL138C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables actin lateral binding activity. Involved in actin filament bundle assembly; cellular bud site selection; and mitotic actomyosin contractile ring assembly. Located in actin filament bundle and cellular bud neck contractile ring. Is active in actin filament. [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See TPM2 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (89230..89715, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Axl2p Neighboring gene Rev7p Neighboring gene Tma108p Neighboring gene Om45p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Crystallization and preliminary X-ray crystallographic analysis of full-length yeast tropomyosin 2 from Saccharomyces cerevisiae. Meshcheryakov V, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008 Jun 1. PMID 18540067, Free PMC Article
  2. Site-specific amino-terminal mutants of yeast-expressed beta-actin. Characterization of the interaction with myosin and tropomyosin. Aspenström P, et al. FEBS Lett, 1992 May 25. PMID 1534298
  3. Roles of type II myosin and a tropomyosin isoform in retrograde actin flow in budding yeast. Huckaba TM, et al. J Cell Biol, 2006 Dec 18. PMID 17178912, Free PMC Article
  4. Modulation of myosin function by isoform-specific properties of Saccharomyces cerevisiae and muscle tropomyosins. Strand J, et al. J Biol Chem, 2001 Sep 14. PMID 11457840
  5. Regulatory properties of tropomyosin effects of length, isoform, and N-terminal sequence. Maytum R, et al. Biochemistry, 2001 Jun 19. PMID 11401582

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin lateral binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament bundle assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular bud site selection IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic actomyosin contractile ring assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in actin filament IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actin filament bundle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in actomyosin contractile ring IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cellular bud neck contractile ring IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tropomyosin TPM2
NP_012128.3
  • Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    89230..89715 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179486.3 → NP_012128.3  TPA: tropomyosin TPM2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012128.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVE8, P40414
    UniProtKB/TrEMBL
    A6ZVD7, B3LTY6, C7GUQ6, C8ZAX5, N1P1V6
    Conserved Domains (1) summary
    pfam12718
    Location:7 → 148
    Tropomyosin_1; Tropomyosin like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40414.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools