RRD1 peptidylprolyl isomerase RRD1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RRD1
Official Full Name: peptidylprolyl isomerase RRD1
Primary source: SGD:S000001415
Locus tag: YIL153W
See related: AllianceGenome:SGD:S000001415; FungiDB:YIL153W; VEuPathDB:YIL153W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: YPA1
Summary: Enables peptidyl-prolyl cis-trans isomerase activity and protein phosphatase regulator activity. Involved in several processes, including G1/S transition of mitotic cell cycle; mitotic spindle organization; and regulation of transcription by RNA polymerase II. Located in chromatin; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in Parkinson's disease 25. Orthologous to human PTPA (protein phosphatase 2 phosphatase activator). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RRD1 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (55198..56379)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Recombinant expression and preliminary characterization of Peptidyl-prolyl cis/trans-isomerase Rrd1 from Saccharomyces cerevisiae.
Title: Recombinant expression and preliminary characterization of Peptidyl-prolyl cis/trans-isomerase Rrd1 from Saccharomyces cerevisiae.
overexpression of RRD1 confers resistance to isoflurane
Title: RRD1, a component of the TORC1 signalling pathway, affects anaesthetic response in Saccharomyces cerevisiae.
specific interaction of Rrd1 with the Tap42-Sit4 complex and that of Rrd2 with the Tap42-Phosphoprotein Phosphatase 2Ac complex
Title: The yeast phosphotyrosyl phosphatase activator is part of the Tap42-phosphatase complexes.
The crystal structures of Ypa1 was determined, revealing an all alpha-helical protein fold that is radically different from other PPIases.
Title: Crystal structure of the PP2A phosphatase activator: implications for its PP2A-specific PPIase activity.
Rrd1 (Ptpa1) forms a complex with Sit4 that mediates repair of oxidative DNA damage caused by 4-nitroquinoline-1-oxide and Ultraviolet A.
Title: The yeast phosphotyrosyl phosphatase activator protein, yPtpa1/Rrd1, interacts with Sit4 phosphatase to mediate resistance to 4-nitroquinoline-1-oxide and UVA.
Mutants lacking either the phosphatase activator Rrd1 or the phosphatase Pph3 are resistant to rapamycin, double mutants exhibit a synergistic response.
Title: The Saccharomyces cerevisiae phosphatase activator RRD1 is required to modulate gene expression in response to rapamycin exposure.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activator activity	IEA Inferred from Electronic Annotation more info
enables protein phosphatase regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein tyrosine phosphatase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G1/S transition of mitotic cell cycle	IPI Inferred from Physical Interaction more info	PubMed
involved_in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to stress	IPI Inferred from Physical Interaction more info	PubMed
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein phosphatase type 2A complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: peptidylprolyl isomerase RRD1

NP_012113.1

EC 5.2.1.8

Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

55198..56379

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179501.1 → NP_012113.1 TPA: peptidylprolyl isomerase RRD1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012113.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVD4, P40454

UniProtKB/TrEMBL

A6ZVC3, C7GUR9, G2WFZ9

Conserved Domains (1) summary

COG5057
Location:1 → 387

LAG1; Phosphotyrosyl phosphatase activator [Cell division and chromosome partitioning / Signal transduction mechanisms]