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VTH1 signal sequence-binding protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 854634, updated on 2-Nov-2024

Summary

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Official Symbol
VTH1
Official Full Name
signal sequence-binding protein
Primary source
SGD:S000001435
Locus tag
YIL173W
See related
AllianceGenome:SGD:S000001435; FungiDB:YIL173W; VEuPathDB:YIL173W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables signal sequence binding activity. Involved in Golgi to vacuole transport. Located in endosome and fungal-type vacuole. Human ortholog(s) of this gene implicated in Alzheimer's disease and abdominal aortic aneurysm. Orthologous to several human genes including SORT1 (sortilin 1) and SORL1 (sortilin related receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See VTH1 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (11492..16141)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene seripauperin PAU14 Neighboring gene pseudo Neighboring gene pseudo Neighboring gene oligo-1,6-glucosidase IMA3 Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Vps10p cycles between the late-Golgi and prevacuolar compartments in its function as the sorting receptor for multiple yeast vacuolar hydrolases. Cooper AA, et al. J Cell Biol, 1996 May. PMID 8636229, Free PMC Article
  2. Multiple pathways for vacuolar sorting of yeast proteinase A. Westphal V, et al. J Biol Chem, 1996 May 17. PMID 8662642
  3. Analysis of an inactivated Lg-FLO1 gene present in bottom-fermenting yeast. Sato M, et al. J Biosci Bioeng, 2002. PMID 16233220
  4. An overexpression screen in Saccharomyces cerevisiae identifies novel genes that affect endocytic protein trafficking. Arlt H, et al. Traffic, 2011 Nov. PMID 21777356
  5. Transfer of the Septin Ring to Cytokinetic Remnants in ER Stress Directs Age-Sensitive Cell-Cycle Re-entry. Chao JT, et al. Dev Cell, 2019 Oct 21. PMID 31564614, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables signal sequence binding IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi to endosome transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to vacuole transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to vacuole transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein targeting to vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vacuolar transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in endosome HDA PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
signal sequence-binding protein
NP_012095.1
  • Putative membrane glycoprotein; has strong similarity to Vth2p and Pep1p/Vps10p; may be involved in vacuolar protein sorting

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    11492..16141
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179519.1 → NP_012095.1  TPA: signal sequence-binding protein [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012095.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C8ZAZ9, D6VVB8, P40438
    Conserved Domains (1) summary
    smart00602
    Location:728 → 1355
    VPS10; VPS10 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40438.1

Gene LinkOut

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