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ATP8 F1F0 ATP synthase subunit 8 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854600, updated on 2-Nov-2024

Summary

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Official Symbol
ATP8
Official Full Name
F1F0 ATP synthase subunit 8
Primary source
SGD:S000007267
Locus tag
Q0080
See related
AllianceGenome:SGD:S000007267; FungiDB:Q0080; VEuPathDB:Q0080
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Saccharomyces cerevisiae S288C (strain: S288C, substrain: FY1679)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
AAP1
Summary
Contributes to proton-transporting ATP synthase activity, rotational mechanism. Involved in proton motive force-driven ATP synthesis. Located in mitochondrion. Part of proton-transporting ATP synthase complex, coupling factor F(o). Used to study mitochondrial metabolism disease. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ATP8 in Genome Data Viewer
Sequence:
Chromosome: MT; NC_001224.1 (27666..27812)

Chromosome MT - NC_001224.1Genomic Context describing neighboring genes Neighboring gene intron-encoded DNA endonuclease aI5 alpha Neighboring gene cytochrome c oxidase subunit 1 Neighboring gene intron-encoded reverse transcriptase aI1 Neighboring gene intron-encoded reverse transcriptase aI2 Neighboring gene intron-encoded DNA endonuclease aI3 Neighboring gene intron-encoded DNA endonuclease aI4 Neighboring gene intron-encoded DNA endonuclease aI5 beta Neighboring gene F1F0 ATP synthase subunit a Neighboring gene tRNA-Glu

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001224.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chemical synthesis of a mitochondrial gene designed for expression in the yeast nucleus. Gearing DP, et al. Biochem Int, 1985 Jun. PMID 2931082
  2. Each yeast mitochondrial F1F0-ATP synthase complex contains a single copy of subunit 8. Stephens AN, et al. Biochim Biophys Acta, 2003 Dec 8. PMID 14670608
  3. Topology and proximity relationships of yeast mitochondrial ATP synthase subunit 8 determined by unique introduced cysteine residues. Stephens AN, et al. Eur J Biochem, 2000 Nov. PMID 11029588
  4. Bioenergetic and structural consequences of allotopic expression of subunit 8 of yeast mitochondrial ATP synthase. The hydrophobic character of residues 23 and 24 is essential for maximal activity and structural stability of the enzyme complex. Roucou X, et al. Eur J Biochem, 1999 Apr. PMID 10215855
  5. Molecular genetic analysis of the central hydrophobic domain of subunit 8 of yeast mitochondrial ATP synthase. Papakonstantinou T, et al. Curr Genet, 1996 Jun. PMID 8662204

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables proton transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to proton-transporting ATP synthase activity, rotational mechanism IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to proton-transporting ATP synthase activity, rotational mechanism IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in ATP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proton motive force-driven ATP synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton motive force-driven ATP synthesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proton motive force-driven ATP synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in proton motive force-driven ATP synthesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of proton-transporting ATP synthase complex, coupling factor F(o) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
Inferred from Electronic Annotation
more info
  
part_of proton-transporting ATP synthase complex, coupling factor F(o) IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
F1F0 ATP synthase subunit 8
NP_009312.1
  • Subunit 8 of the F0 sector of mitochondrial F1F0 ATP synthase; encoded on the mitochondrial genome; ATP8 and ATP6 mRNAs are not translated in the absence of the F1 sector of ATPase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001224.1 Reference assembly

    Range
    27666..27812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_009312.1 F1F0 ATP synthase subunit 8 (mitochondrion) [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009312.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    A0A0A7P362, P00856
    UniProtKB/TrEMBL
    A0A0G3F1I9, A7LCN6, C7GSD7, G2HKE2, Q7GHK0
    Conserved Domains (1) summary
    pfam05933
    Location:1 → 48
    Fun_ATP-synt_8; Fungal ATP synthase protein 8 (A6L)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00856.1

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