OLI1 F0 ATP synthase subunit c [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: OLI1
Official Full Name: F0 ATP synthase subunit c
Primary source: SGD:S000007274
Locus tag: Q0130
See related: AllianceGenome:SGD:S000007274; FungiDB:Q0130; VEuPathDB:Q0130
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Saccharomyces cerevisiae S288C (strain: S288C, substrain: FY1679)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ATP9; OLI3
Summary: Contributes to ATP hydrolysis activity and proton-transporting ATP synthase activity, rotational mechanism. Involved in ATP synthesis coupled proton transport. Located in mitochondrion. Part of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See OLI1 in Genome Data Viewer

Sequence:: Chromosome: MT; NC_001224.1 (46723..46953)

Chromosome MT - NC_001224.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001224.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Allotopic expression of COX6 elucidates Atco-driven co-assembly of cytochrome oxidase and ATP synthase.
Title: Allotopic expression of COX6 elucidates Atco-driven co-assembly of cytochrome oxidase and ATP synthase.
Data indicate cardiolipin interacts with the c10-ring in the ATP synthase from Saccharomyces cerevisiae .
Title: Cardiolipin binds selectively but transiently to conserved lysine residues in the rotor of metazoan ATP synthases.
rotor component assembly of yeast mitochondrial ATP synthase is enhanced when Atp9p is supplied by Atp9p-Cox6p complexes
Title: Assembly of the rotor component of yeast mitochondrial ATP synthase is enhanced when Atp9p is supplied by Atp9p-Cox6p complexes.
ATP9B is able to exit the ER and localize to the TGN independently of CDC50 proteins and this protein contains a Golgi localization signal in its N-terminal cytoplasmic region
Title: ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner.
report a new nuclear gene, designated ATP25 (reading frame YMR098C on chromosome XIII), required for expression of Atp9p (subunit 9) of the mitochondrial proton translocating ATPase
Title: ATP25, a new nuclear gene of Saccharomyces cerevisiae required for expression and assembly of the Atp9p subunit of mitochondrial ATPase.
presequence either targets Atp6p to the Atp9p or signals insertion of the Atp6p precursor into a microcompartment of the membrane for more efficient interaction with the Atp9p ring.
Title: The leader peptide of yeast Atp6p is required for efficient interaction with the Atp9p ring of the mitochondrial ATPase.
a mutation in mitochondrial F(1)F(0)-ATP synthase prevents the synthesis of the two mtDNA-encoded subunits (Atp6p and Atp9p) forming the core of this channel
Title: A "petite obligate" mutant of Saccharomyces cerevisiae: functional mtDNA is lethal in cells lacking the delta subunit of mitochondrial F1-ATPase.
by directly interacting with newly synthesized Atp9 in a posttranslational manner, Oxa1 is required to maintain the assembly competence of the Atp9-F(1)-subcomplex for its association with Atp6
Title: Oxa1 directly interacts with Atp9 and mediates its assembly into the mitochondrial F1Fo-ATP synthase complex.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables proton transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
contributes_to proton-transporting ATP synthase activity, rotational mechanism	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in proton motive force-driven ATP synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton motive force-driven ATP synthesis	IDA Inferred from Direct Assay more info	PubMed
involved_in proton motive force-driven ATP synthesis	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of proton-transporting ATP synthase complex, coupling factor F(o)	IBA Inferred from Biological aspect of Ancestor more info
part_of proton-transporting ATP synthase complex, coupling factor F(o)	IEA Inferred from Electronic Annotation more info
part_of proton-transporting ATP synthase complex, coupling factor F(o)	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: F0 ATP synthase subunit c

NP_009319.1

F0-ATP synthase subunit c (ATPase-associated proteolipid); encoded on the mitochondrial genome; mutation confers oligomycin resistance; expression is specifically dependent on the nuclear genes AEP1 and AEP2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001224.1 Reference assembly

Range

46723..46953

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_009319.1 F0 ATP synthase subunit c (mitochondrion) [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009319.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

A0A0A7P075, P00841, P61829, Q37750

UniProtKB/TrEMBL

A0A0G3F489, A7LCN9, C7GM63, E9PA19, E9PA20, G2HKE8

Conserved Domains (1) summary

cd18182
Location:8 → 72

ATP-synt_Fo_c_ATP5G3; ATP synthase F(0) complex subunit C3 (ATP5G3) and similar proteins