SNX3 Snx3p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SNX3
Official Full Name: Snx3p
Primary source: SGD:S000005884
Locus tag: YOR357C
See related: AllianceGenome:SGD:S000005884; FungiDB:YOR357C; VEuPathDB:YOR357C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: GRD19
Summary: Enables phosphatidylinositol-3-phosphate binding activity. Involved in late endosome to Golgi transport and protein localization. Located in cytosol and endosome. Orthologous to human SNX12 (sorting nexin 12) and SNX3 (sorting nexin 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SNX3 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (1009224..1009712, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In the presence and absence of iron, Fet3-Ftr1 transits an endosomal compartment where a subunit of the multivesicular body sorting receptor (Vps27), Snx3/Grd19, and retromer proteins colocalize.
Title: Opposing activities of the Snx3-retromer complex and ESCRT proteins mediate regulated cargo sorting at a common endosome.
Grd19/Snx3p functions as a cargo-specific adapter for the retromer complex, establishing a precedent for a mechanism by which sorting nexins expand the repertoire of retromer-dependent cargos.
Title: Grd19/Snx3p functions as a cargo-specific adapter for retromer-dependent endocytic recycling.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3-phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in late endosome to Golgi transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in late endosome to Golgi transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in early endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in fungal-type vacuole membrane	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of retromer complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Snx3p

NP_015002.3

Sorting nexin for late-Golgi enzymes; required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

1009224..1009712 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183777.3 → NP_015002.3 TPA: Snx3p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015002.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W352, Q08826

UniProtKB/TrEMBL

A6ZPI7, B3LK14, B5VSN5, C7GNR1, C8ZHA7, G2WNL8, N1NXJ1

Conserved Domains (1) summary

cd07295
Location:35 → 160

PX_Grd19; The phosphoinositide binding Phox Homology domain of fungal Grd19