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CIN1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854531, updated on 22-Aug-2024

Summary

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Official Symbol
CIN1
Primary source
FungiDB:YOR349W
Locus tag
YOR349W
See related
SGD:S000005876; AllianceGenome:SGD:S000005876; VEuPathDB:YOR349W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable GTPase activator activity and beta-tubulin binding activity. Involved in protein folding and tubulin complex assembly. Orthologous to human TBCD (tubulin folding cofactor D). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (989789..992833)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene pyruvate kinase PYK2 Neighboring gene proline permease PUT4 Neighboring gene Mne1p Neighboring gene serine/threonine protein kinase MEK1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chromosome instability mutants of Saccharomyces cerevisiae that are defective in microtubule-mediated processes. Hoyt MA, et al. Mol Cell Biol, 1990 Jan. PMID 2403635, Free PMC Article
  2. Tubulin cofactors and Arl2 are cage-like chaperones that regulate the soluble αβ-tubulin pool for microtubule dynamics. Nithianantham S, et al. Elife, 2015 Jul 24. PMID 26208336, Free PMC Article
  3. A potential role of the cytoskeleton of Saccharomyces cerevisiae in a functional organization of glycolytic enzymes. Götz R, et al. Yeast, 1999 Nov. PMID 10572259
  4. Yeast mutants sensitive to antimicrotubule drugs define three genes that affect microtubule function. Stearns T, et al. Genetics, 1990 Feb. PMID 2407611, Free PMC Article
  5. Protection from free beta-tubulin by the beta-tubulin binding protein Rbl2p. Abruzzi KC, et al. Mol Cell Biol, 2002 Jan. PMID 11739729, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables beta-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-tubulin binding IEA
Inferred from Electronic Annotation
more info
  
enables beta-tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in post-chaperonin tubulin folding pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein folding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in tubulin complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in tubulin complex assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in tubulin complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
Cin1p
NP_014994.3
  • Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; CIN1 mRNA level is reduced when downstream gene MNE1 is deleted

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    989789..992833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183769.3 → NP_014994.3  TPA: Cin1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014994.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W344, P40987
    UniProtKB/TrEMBL
    A6ZPH9, C7GNR9, C8ZHA0, N1NYZ9
    Conserved Domains (1) summary
    COG5234
    Location:1 → 1012
    CIN1; Beta-tubulin folding cofactor D [Posttranslational modification, protein turnover, chaperones / Cytoskeleton]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40987.1

Gene LinkOut

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