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MRS2 Mrs2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854511, updated on 2-Nov-2024

Summary

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Official Symbol
MRS2
Official Full Name
Mrs2p
Primary source
SGD:S000005861
Locus tag
YOR334W
See related
AllianceGenome:SGD:S000005861; FungiDB:YOR334W; VEuPathDB:YOR334W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables cardiolipin binding activity and magnesium ion transmembrane transporter activity. Involved in mitochondrial magnesium ion transmembrane transport. Located in mitochondrion. Is active in mitochondrial inner membrane. Used to study Barth syndrome. Orthologous to human MRS2 (magnesium transporter MRS2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MRS2 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (944596..946008)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene DNA-directed DNA polymerase gamma MIP1 Neighboring gene H(+)-transporting V1 sector ATPase subunit E Neighboring gene alanine--tRNA ligase Neighboring gene Kre5p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cardiolipin deficiency leads to the destabilization of mitochondrial magnesium channel MRS2 in Barth syndrome. Joshi A, et al. Hum Mol Genet, 2023 Dec 1. PMID 37721533
  2. Crystallization and preliminary X-ray diffraction analysis of the N-terminal domain of Mrs2, a magnesium ion transporter from yeast inner mitochondrial membrane. Khan MB, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Jun 1. PMID 20516593, Free PMC Article
  3. The G-M-N motif determines ion selectivity in the yeast magnesium channel Mrs2p. Sponder G, et al. Metallomics, 2013 Jun. PMID 23686104
  4. Structural and functional characterization of the N-terminal domain of the yeast Mg2+ channel Mrs2. Khan MB, et al. Acta Crystallogr D Biol Crystallogr, 2013 Sep. PMID 23999289
  5. Mutant alleles of the MRS2 gene of yeast nuclear DNA suppress mutations in the catalytic core of a mitochondrial group II intron. Schmidt U, et al. J Mol Biol, 1998 Sep 25. PMID 9737920

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A functional and structural analysis of the regulatory domain of the eukaryotic divalent magnesium 2+ channel Mrs2 from yeast inner mitochondrial membrane is presented.
    Title: Structural and functional characterization of the N-terminal domain of the yeast Mg2+ channel Mrs2.
  2. inner mitochondrial domain of the Mrs2 from Saccharomyces cerevisae was overexpressed, purified and crystallized in two different crystal forms. The crystals diffracted X-rays to 1.83 and 4.16 A resolution, respectively.
    Title: Crystallization and preliminary X-ray diffraction analysis of the N-terminal domain of Mrs2, a magnesium ion transporter from yeast inner mitochondrial membrane.
  3. The Mrs2p is of central significance for the transport of Mg(2+) into mitochondria of S. cerevisiae.
    Title: Lpe10p modulates the activity of the Mrs2p-based yeast mitochondrial Mg2+ channel.
  4. Data presented support the notion that effects of mutations in Mrs2p on group II intron splicing are a consequence of changes in steady-state mitochondrial Mg2+ concentrations.
    Title: Mutational analysis of functional domains in Mrs2p, the mitochondrial Mg2+ channel protein of Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cardiolipin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial magnesium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial magnesium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial magnesium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mrs2p
NP_014979.1
  • Mitochondrial inner membrane Mg(2+) channel; required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns; similar to bacterial CorA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    944596..946008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183754.1 → NP_014979.1  TPA: Mrs2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014979.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W329, Q01926
    UniProtKB/TrEMBL
    A6ZPG4, B3LJZ3, C7GNT2, C8ZH86, N1NX14
    Conserved Domains (1) summary
    cd12823
    Location:66 → 374
    Mrs2_Mfm1p-like; Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01926.2

Gene LinkOut

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