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LDB19 Ldb19p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854500, updated on 3-Nov-2024

Summary

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Official Symbol
LDB19
Official Full Name
Ldb19p
Primary source
SGD:S000005849
Locus tag
YOR322C
See related
AllianceGenome:SGD:S000005849; FungiDB:YOR322C; VEuPathDB:YOR322C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ART1
Summary
Enables ubiquitin protein ligase binding activity. Involved in cellular response to amino acid stimulus; positive regulation of receptor internalization; and ubiquitin-dependent endocytosis. Located in Golgi trans cisterna; cytosol; and plasma membrane. Orthologous to several human genes including ARRDC1 (arrestin domain containing 1); ARRDC2 (arrestin domain containing 2); and ARRDC3 (arrestin domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See LDB19 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (918606..921062, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene glucose N-acetyltransferase Neighboring gene dolichyl-phosphate-mannose-protein mannosyltransferase PMT3 Neighboring gene glutamate-5-semialdehyde dehydrogenase Neighboring gene Frt1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence of a role for S. cerevisiae α-arrestin Art1 (Ldb19) in mating projection and zygote formations. Choudhary P, et al. Cell Biol Int, 2016 Jan. PMID 26314564
  2. A genome-wide screen for Saccharomyces cerevisiae nonessential genes involved in mannosyl phosphate transfer to mannoprotein-linked oligosaccharides. Corbacho I, et al. Fungal Genet Biol, 2005 Sep. PMID 15993632
  3. Hypo-osmotic-like stress underlies general cellular defects of aneuploidy. Tsai HJ, et al. Nature, 2019 Jun. PMID 31068692, Free PMC Article
  4. A Snf1-related nutrient-responsive kinase antagonizes endocytosis in yeast. Tumolo JM, et al. PLoS Genet, 2020 Mar. PMID 32191698, Free PMC Article
  5. TORC1 regulates endocytosis via Npr1-mediated phosphoinhibition of a ubiquitin ligase adaptor. MacGurn JA, et al. Cell, 2011 Nov 23. PMID 22118465

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Findings implicate Art1 in selective regulation of mating events downstream of receptor internalization and cell cycle arrest, leading to schmoo, and ultimately zygote formation.
    Title: Evidence of a role for S. cerevisiae α-arrestin Art1 (Ldb19) in mating projection and zygote formations.
  2. Evidence prove that Ldb19 and Rod1 recruit Rsp5 to Ste2 for its internalization.
    Title: Specific α-arrestins negatively regulate Saccharomyces cerevisiae pheromone response by down-modulating the G-protein-coupled receptor Ste2.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to amino acid stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of receptor internalization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of receptor internalization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent endocytosis IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi trans cisterna IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Ldb19p
NP_014967.3
  • Alpha-arrestin, Ub-ligase adaptor for Rsp5p; regulates starvation- and substrate-induced Ub-dependent endocytosis of select plasma membrane localized amino acid transporters, recruiting Rsp5p to its targets; role in basal internalization and turnover of Ste2p, mating and zygote formation; recruits Rsp5p to Ste2p via its 2 PPXY motifs; inhibited by Npr1p-mediated phosphorylation, affecting cytosol and plasma membrane translocation; localization regulated by Rsp5p-dependent ubiquitination

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    918606..921062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183742.3 → NP_014967.3  TPA: Ldb19p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014967.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W320, Q12502
    UniProtKB/TrEMBL
    A6ZPF5, B3LJY4, C7GNU1, C8ZH73, G2WNI7, N1NX08
    Conserved Domains (1) summary
    pfam13002
    Location:144 → 346
    LDB19; Arrestin_N terminal like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12502.1

Gene LinkOut

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