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HSH49 U2 snRNP complex subunit HSH49 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854497, updated on 18-Sep-2024

Summary

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Official Symbol
HSH49
Official Full Name
U2 snRNP complex subunit HSH49
Primary source
SGD:S000005846
Locus tag
YOR319W
See related
AllianceGenome:SGD:S000005846; FungiDB:YOR319W; VEuPathDB:YOR319W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Part of U2 snRNP and U2-type prespliceosome. Human ortholog(s) of this gene implicated in Nager acrofacial dysostosis. Orthologous to human SF3B4 (splicing factor 3b subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See HSH49 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (912822..913463)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long-chain fatty acid-CoA ligase FAA1 Neighboring gene glucose N-acetyltransferase Neighboring gene dolichyl-phosphate-mannose-protein mannosyltransferase PMT3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Selective aggregation of the splicing factor Hsh155 suppresses splicing upon genotoxic stress. Mathew V, et al. J Cell Biol, 2017 Dec 4. PMID 28978642, Free PMC Article
  2. Crystal structure of U2 snRNP SF3b components: Hsh49p in complex with Cus1p-binding domain. van Roon AM, et al. RNA, 2017 Jun. PMID 28348170, Free PMC Article
  3. Conservation of structure and subunit interactions in yeast homologues of splicing factor 3b (SF3b) subunits. Igel H, et al. RNA, 1998 Jan. PMID 9436903, Free PMC Article
  4. Functional Cus1p is found with Hsh155p in a multiprotein splicing factor associated with U2 snRNA. Pauling MH, et al. Mol Cell Biol, 2000 Mar. PMID 10688664, Free PMC Article
  5. CUS1, a suppressor of cold-sensitive U2 snRNA mutations, is a novel yeast splicing factor homologous to human SAP 145. Wells SE, et al. Genes Dev, 1996 Jan 15. PMID 8566755

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of U2 snRNP IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U2-type prespliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
U2 snRNP complex subunit HSH49
NP_014964.1
  • U2-snRNP associated splicing factor; similar to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    912822..913463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183739.1 → NP_014964.1  TPA: U2 snRNP complex subunit HSH49 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014964.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W317, Q99181
    UniProtKB/TrEMBL
    A6ZPF2, B3LJY2, B5VSJ3, C7GNU4, C8ZH70, G2WNI4, N1NW79
    Conserved Domains (2) summary
    TIGR01628
    Location:10 → 208
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12334
    Location:11 → 85
    RRM1_SF3B4; RNA recognition motif 1 (RRM1) found in splicing factor 3B subunit 4 (SF3B4) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99181.1

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