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RAX1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854477, updated on 22-Aug-2024

Summary

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Official Symbol
RAX1
Primary source
FungiDB:YOR301W
Locus tag
YOR301W
See related
SGD:S000005827; AllianceGenome:SGD:S000005827; VEuPathDB:YOR301W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in axial cellular bud site selection; bipolar cellular bud site selection; and cellular protein localization. Located in cellular bud neck and cellular bud scar. Orthologous to human AKAP10 (A-kinase anchoring protein 10). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (880965..882272)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene multiprotein-bridging factor 1 Neighboring gene exomer complex subunit Neighboring gene uncharacterized protein Neighboring gene carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multigenerational cortical inheritance of the Rax2 protein in orienting polarity and division in yeast. Chen T, et al. Science, 2000 Dec 8. PMID 11110666
  2. Mitotic and pheromone-specific intrinsic polarization cues interfere with gradient sensing in Saccharomyces cerevisiae. Vasen G, et al. Proc Natl Acad Sci U S A, 2020 Mar 24. PMID 32152126, Free PMC Article
  3. Sequential logic of polarity determination during the haploid-to-diploid transition in Saccharomyces cerevisiae. Zapanta Rinonos S, et al. Eukaryot Cell, 2014 Nov. PMID 25172767, Free PMC Article
  4. Distinct domains of yeast cortical tag proteins Bud8p and Bud9p confer polar localization and functionality. Krappmann AB, et al. Mol Biol Cell, 2007 Sep. PMID 17581861, Free PMC Article
  5. Interactions among Rax1p, Rax2p, Bud8p, and Bud9p in marking cortical sites for bipolar bud-site selection in yeast. Kang PJ, et al. Mol Biol Cell, 2004 Nov. PMID 15356260, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rax1p and Rax2p interact closely with each other and with Bud8p and Bud9p in the establishment and/or maintenance of the cortical landmarks for bipolar budding
    Title: Interactions among Rax1p, Rax2p, Bud8p, and Bud9p in marking cortical sites for bipolar bud-site selection in yeast.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in axial cellular bud site selection IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in bipolar cellular bud site selection IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in bipolar cellular bud site selection IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud scar IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud tip IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rax1p
NP_014945.3
  • Protein involved in establishing bud site selection; localizes to the bud neck and previous sites of cell division (bud scars or cytokinesis remnants (CRMs); localization to both sites is interdependent with Rax2p; required with Rax2p to anchor Nba1p and Nis1p to CRMs where a Cdc42p inhibitory zone is established, preventing repolarization of cells at previous division sites; predicted type IIIa transmembrane protein with similarity to members of the insulin-related peptide superfamily

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    880965..882272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183720.3 → NP_014945.3  TPA: Rax1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014945.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W300, Q08760
    UniProtKB/TrEMBL
    A6ZPD6, B3LJW5, C7GNW0, G2WNG7, N1NYW6
    Conserved Domains (1) summary
    smart00315
    Location:189 → 255
    RGS; Regulator of G protein signalling domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08760.1

Gene LinkOut

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