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MBF1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854474, updated on 11-Sep-2024

Summary

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Official Symbol
MBF1
Primary source
SGD:S000007253
Locus tag
YOR298C-A
See related
AllianceGenome:SGD:S000007253; FungiDB:YOR298C-A; VEuPathDB:YOR298C-A
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SUF13
Summary
Enables transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Located in mitochondrion. Orthologous to human EDF1 (endothelial differentiation related factor 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (877230..877685, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Tim18p Neighboring gene Mum3p Neighboring gene exomer complex subunit Neighboring gene Rax1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The potato transcriptional co-activator StMBF1 is up-regulated in response to oxidative stress and interacts with the TATA-box binding protein. Arce DP, et al. J Biochem Mol Biol, 2006 Jul 31. PMID 16889677
  2. Multiprotein-bridging factor 1 regulates vegetative growth, osmotic stress, and virulence in Magnaporthe oryzae. Fan G, et al. Curr Genet, 2017 May. PMID 27485943
  3. Compensatory change of interacting amino acids in the coevolution of transcriptional coactivator MBF1 and TATA-box-binding protein. Liu QX, et al. Mol Biol Evol, 2007 Jul. PMID 17440176
  4. Frameshift suppression in Saccharomyces cerevisiae. V. Isolation and genetic properties of nongroup-specific suppressors. Culbertson MR, et al. Genetics, 1982 Nov. PMID 6757053, Free PMC Article
  5. Primary structure of wild-type and mutant alleles of the PET494 gene of Saccharomyces cerevisiae. Costanzo MC, et al. Mol Gen Genet, 1986 Feb. PMID 3010052

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mbf1 and Rps3 cooperate to maintain the reading frame of stalled ribosomes, while Asc1 also mediates distinct events that result in recruitment of the ribosome quality control complex and mRNA decay.
    Title: Multi-protein bridging factor 1(Mbf1), Rps3 and Asc1 prevent stalled ribosomes from frameshifting.
  2. evidence for compensatory changes of transcription coactivator and its interacting target, presenting the report that transcription coactivator may have undergone coevolution with TBP
    Title: Compensatory change of interacting amino acids in the coevolution of transcriptional coactivator MBF1 and TATA-box-binding protein.
  3. A negative feedback loop involving Nrm1 bound to MBF leads to transcriptional repression as cells exit G1 phase.
    Title: Constraining G1-specific transcription to late G1 phase: the MBF-associated corepressor Nrm1 acts via negative feedback.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
multiprotein-bridging factor 1
NP_014942.4
  • Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    877230..877685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184346.3 → NP_014942.4  TPA: multiprotein-bridging factor 1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014942.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2Z8, O14467, Q7LGJ8, Q86ZS7
    UniProtKB/TrEMBL
    A6ZPD4, B3LJW3, C7GNW2, C8ZH49, G2WNG5, N1P3R3
    Conserved Domains (2) summary
    COG1813
    Location:46 → 150
    aMBF1; Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis]
    pfam08523
    Location:3 → 75
    MBF1; Multiprotein bridging factor 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O14467.2

Gene LinkOut

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