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UAF30 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854470, updated on 11-Sep-2024

Summary

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Official Symbol
UAF30
Primary source
SGD:S000005821
Locus tag
YOR295W
See related
AllianceGenome:SGD:S000005821; FungiDB:YOR295W; VEuPathDB:YOR295W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA polymerase I cis-regulatory region sequence-specific DNA binding activity and RNA polymerase I general transcription initiation factor activity. Involved in chromatin organization and nucleolar large rRNA transcription by RNA polymerase I. Located in nucleolus. Part of RNA polymerase I upstream activating factor complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (869208..869894)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rrs1p Neighboring gene uncharacterized protein Neighboring gene Tim18p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcription of multiple yeast ribosomal DNA genes requires targeting of UAF to the promoter by Uaf30. Hontz RD, et al. Mol Cell Biol, 2008 Nov. PMID 18765638, Free PMC Article
  2. Non-Coding, RNAPII-Dependent Transcription at the Promoters of rRNA Genes Regulates Their Chromatin State in S. cerevisiae. Lesage E, et al. Noncoding RNA, 2021 Jul 11. PMID 34287362, Free PMC Article
  3. Genomic Copy-Number Loss Is Rescued by Self-Limiting Production of DNA Circles. Mansisidor A, et al. Mol Cell, 2018 Nov 1. PMID 30293780, Free PMC Article
  4. Alternative chromatin structures of the 35S rRNA genes in Saccharomyces cerevisiae provide a molecular basis for the selective recruitment of RNA polymerases I and II. Goetze H, et al. Mol Cell Biol, 2010 Apr. PMID 20154141, Free PMC Article
  5. The Transcription Factor THO Promotes Transcription Initiation and Elongation by RNA Polymerase I. Zhang Y, et al. J Biol Chem, 2016 Feb 5. PMID 26663077, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA polymerase I cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase I cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase I general transcription initiation factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleolar large rRNA transcription by RNA polymerase I IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleolar large rRNA transcription by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription initiation at RNA polymerase I promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA polymerase I upstream activating factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase I upstream activating factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Uaf30p
NP_014938.3
  • Subunit of UAF (upstream activation factor) complex; UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; targeting factor for the UAF that facilitates activation of many rDNA genes; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    869208..869894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183714.3 → NP_014938.3  TPA: Uaf30p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014938.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2Z4, Q08747
    UniProtKB/TrEMBL
    B3LJW0, B5VSH3, C7GNW6, C8ZH45, N1NVY7
    Conserved Domains (1) summary
    COG5531
    Location:1 → 228
    Rsc6; Chromatin remodeling complex protein RSC6, contains SWIB domain [Chromatin structure and dynamics]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08747.1

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