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GPN2 putative GTPase GPN2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854436, updated on 2-Nov-2024

Summary

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Official Symbol
GPN2
Official Full Name
putative GTPase GPN2
Primary source
SGD:S000005788
Locus tag
YOR262W
See related
AllianceGenome:SGD:S000005788; FungiDB:YOR262W; VEuPathDB:YOR262W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable GTPase activity. Involved in establishment of mitotic sister chromatid cohesion and protein import into nucleus. Located in cytoplasm. Orthologous to human GPN2 (GPN-loop GTPase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See GPN2 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (817292..818335)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene translation initiation factor eIF2B subunit gamma Neighboring gene proteasome regulatory particle lid subunit RPN8 Neighboring gene Dse3p Neighboring gene Rbl2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gpn2 and Rba50 Directly Participate in the Assembly of the Rpb3 Subcomplex in the Biogenesis of RNA Polymerase II. Zeng F, et al. Mol Cell Biol, 2018 Jul 1. PMID 29661922, Free PMC Article
  2. Biogenesis of RNA polymerases II and III requires the conserved GPN small GTPases in Saccharomyces cerevisiae. Minaker SW, et al. Genetics, 2013 Mar. PMID 23267056, Free PMC Article
  3. Npa3 interacts with Gpn3 and assembly factor Rba50 for RNA polymerase II biogenesis. Liu X, et al. FASEB J, 2020 Nov. PMID 32985767
  4. Eukaryotic GPN-loop GTPases paralogs use a dimeric assembly reminiscent of archeal GPN. Alonso B, et al. Cell Cycle, 2013 Feb 1. PMID 23324351, Free PMC Article
  5. GTP-dependent binding and nuclear transport of RNA polymerase II by Npa3 protein. Staresincic L, et al. J Biol Chem, 2011 Oct 14. PMID 21844196, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results suggest that the GPN proteins (GPN2 and GPN3) function upstream of Iwr1 in RNA polymerase II and III biogenesis.
    Title: Biogenesis of RNA polymerases II and III requires the conserved GPN small GTPases in Saccharomyces cerevisiae.
  2. These results suggest that yGPN1 and yGPN2, yGPN3 proteins act at the molecular level in sister chromatid cohesion mechanism as a GPN|GPN complex.
    Title: Eukaryotic GPN-loop GTPases paralogs use a dimeric assembly reminiscent of archeal GPN.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in establishment of mitotic sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative GTPase GPN2
NP_014905.1
  • Putative GTPase with a specific role in RNA pol II and polIII biogenesis; involved in the assembly and subsequent nuclear import of RNA polymerases II and III; required for establishment of sister chromatid cohesion; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn3p; highly conserved across species and homologous to human gene GPN2/ATPBD1B

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    817292..818335
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183681.1 → NP_014905.1  TPA: putative GTPase GPN2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014905.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2W3, Q08726
    UniProtKB/TrEMBL
    A6ZPA0, B3LJT0, B5VSE3, C7GWC7, C8ZH13, G2WND0, N1NXB3
    Conserved Domains (1) summary
    cd17871
    Location:3 → 257
    GPN2; GPN-loop GTPase 2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08726.1

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