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LIP5 putative lipoate synthase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854371, updated on 2-Nov-2024

Summary

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Official Symbol
LIP5
Official Full Name
putative lipoate synthase
Primary source
SGD:S000005722
Locus tag
YOR196C
See related
AllianceGenome:SGD:S000005722; FungiDB:YOR196C; VEuPathDB:YOR196C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable lipoate synthase activity. Involved in protein lipoylation. Located in mitochondrion. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human LIAS (lipoic acid synthetase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See LIP5 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (715593..716837, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene transcription initiation factor IIA large subunit Neighboring gene Slk19p Neighboring gene Ca(2+)-dependent cysteine protease MCA1 Neighboring gene Bfr1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Alpha-Ketoglutarate dehydrogenase and lipoic acid synthase are important for the functioning of peroxisomes of Saccharomyces cerevisiae. Smaczyńska-de Rooij I, et al. Cell Mol Biol Lett, 2004. PMID 15213808
  2. Lipoic acid synthesis and attachment in yeast mitochondria. Schonauer MS, et al. J Biol Chem, 2009 Aug 28. PMID 19570983, Free PMC Article
  3. Functional Reconstitution of a Pyruvate Dehydrogenase in the Cytosol of Saccharomyces cerevisiae through Lipoylation Machinery Engineering. Lian J, et al. ACS Synth Biol, 2016 Jul 15. PMID 26991359
  4. Structural and mechanistic studies of VPS4 proteins. Scott A, et al. EMBO J, 2005 Oct 19. PMID 16193069, Free PMC Article
  5. Genetic analysis of desiccation tolerance in Sachharomyces cerevisiae. Calahan D, et al. Genetics, 2011 Oct. PMID 21840858, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results presented indicate that the alpha-ketoglutarate dehydrogenase complex and lipoic acid synthase are important for the proper functioning of peroxisomes.
    Title: Alpha-Ketoglutarate dehydrogenase and lipoic acid synthase are important for the functioning of peroxisomes of Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables lipoate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipoate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables lipoate synthase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipoate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipoate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein lipoylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein lipoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative lipoate synthase
NP_014839.1
  • Protein involved in biosynthesis of the coenzyme lipoic acid; has similarity to E. coli lipoic acid synthase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    715593..716837 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183615.1 → NP_014839.1  TPA: putative lipoate synthase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014839.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZP42, B3LJM6, B5VS81, C7GWI3, C8ZGV5, D6W2Q5, P32875
    UniProtKB/TrEMBL
    G2WN71, N1NYL8
    Conserved Domains (1) summary
    TIGR00510
    Location:104 → 411
    lipA; lipoate synthase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32875.1

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