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SYC1 cleavage polyadenylation factor subunit SYC1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854351, updated on 2-Nov-2024

Summary

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Official Symbol
SYC1
Official Full Name
cleavage polyadenylation factor subunit SYC1
Primary source
SGD:S000005705
Locus tag
YOR179C
See related
AllianceGenome:SGD:S000005705; FungiDB:YOR179C; VEuPathDB:YOR179C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable RNA binding activity. Involved in negative regulation of mRNA 3'-end processing. Located in nucleus. Part of mRNA cleavage and polyadenylation specificity factor complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SYC1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (671845..672411, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Mpc54p Neighboring gene protein phosphatase regulator GAC1 Neighboring gene putative dodecenoyl-CoA isomerase DCI1 Neighboring gene actin-binding protein LAS17

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The role of the Brr5/Ysh1 C-terminal domain and its homolog Syc1 in mRNA 3'-end processing in Saccharomyces cerevisiae. Zhelkovsky A, et al. RNA, 2006 Mar. PMID 16431986, Free PMC Article
  2. Architecture of eukaryotic mRNA 3'-end processing machinery. Casañal A, et al. Science, 2017 Nov 24. PMID 29074584, Free PMC Article
  3. Functional interactions between the transcription and mRNA 3' end processing machineries mediated by Ssu72 and Sub1. He X, et al. Genes Dev, 2003 Apr 15. PMID 12704082, Free PMC Article
  4. The APT complex is involved in non-coding RNA transcription and is distinct from CPF. Lidschreiber M, et al. Nucleic Acids Res, 2018 Nov 30. PMID 30247719, Free PMC Article
  5. The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4. Roguev A, et al. EMBO J, 2001 Dec 17. PMID 11742990, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Syc1 plays a more important role in snoRNA production.Syc1 is the defining subunit of a distinct APT complex, and is not part of CPF complex.
    Title: The APT complex is involved in non-coding RNA transcription and is distinct from CPF.
  2. Syc1, by mimicking the essential Brr5 C-terminus, serves as a negative regulator of mRNA 3'-end formation.
    Title: The role of the Brr5/Ysh1 C-terminal domain and its homolog Syc1 in mRNA 3'-end processing in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IC
Inferred by Curator
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of mRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of mRNA cleavage and polyadenylation specificity factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cleavage polyadenylation factor subunit SYC1
NP_014822.1
  • Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    671845..672411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183598.1 → NP_014822.1  TPA: cleavage polyadenylation factor subunit SYC1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014822.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2N5, Q08553
    UniProtKB/TrEMBL
    B5VS64, C7GLR4, N1P3B5
    Conserved Domains (1) summary
    cl13209
    Location:28 → 186
    CPSF73-100_C; Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08553.1

Gene LinkOut

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