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RPS28A ribosomal 40S subunit protein S28A [ Saccharomyces cerevisiae S288C ]

Gene ID: 854338, updated on 3-Nov-2024

Summary

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Official Symbol
RPS28A
Official Full Name
ribosomal 40S subunit protein S28A
Primary source
SGD:S000005693
Locus tag
YOR167C
See related
AllianceGenome:SGD:S000005693; FungiDB:YOR167C; VEuPathDB:YOR167C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RPS33A
Summary
A structural constituent of ribosome. Involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay and ribosomal subunit export from nucleus. Part of cytosolic small ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 15 with mandibulofacial dysostosis. Orthologous to human RPS28 (ribosomal protein S28). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RPS28A in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (648804..649007, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene dynamin-like GTPase SEY1 Neighboring gene mRNA-processing endoribonuclease Neighboring gene glutamine--tRNA ligase Neighboring gene sphinganine kinase LCB4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast ribosomal protein S33 is encoded by an unsplit gene. Leer RJ, et al. Nucleic Acids Res, 1983 Nov 25. PMID 6196722, Free PMC Article
  2. Transcription activation of yeast ribosomal protein genes requires additional elements apart from binding sites for Abf1p or Rap1p. Gonçalves PM, et al. Nucleic Acids Res, 1995 May 11. PMID 7784199, Free PMC Article
  3. Different roles for abf1p and a T-rich promoter element in nucleosome organization of the yeast RPS28A gene. Lascaris RF, et al. Nucleic Acids Res, 2000 Mar 15. PMID 10684934, Free PMC Article
  4. Ribosomal protein gene transcription in Saccharomyces cerevisiae shows a biphasic response to nutritional changes. Griffioen G, et al. Microbiology (Reading), 1996 Aug. PMID 8760940
  5. Dissection of Dom34-Hbs1 reveals independent functions in two RNA quality control pathways. van den Elzen AM, et al. Nat Struct Mol Biol, 2010 Dec. PMID 21102444

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal small subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal subunit export from nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosomal 40S subunit protein S28A
NP_014810.1
  • Protein component of the small (40S) ribosomal subunit; has an extraribosomal function in regulation of RPS28B, in which Rps28Ap binds to a decapping complex via Edc3p, which then binds to RPS28B mRNA leading to its decapping and degradation; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28A has a paralog, RPS28B, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    648804..649007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183586.1 → NP_014810.1  TPA: ribosomal 40S subunit protein S28A [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014810.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2M5, P02380, Q3E7X9
    UniProtKB/TrEMBL
    A6ZP12, B3LJK0, C7GN57, C8ZGS8, G2WN40, N1NVT8
    Conserved Domains (1) summary
    cd04457
    Location:8 → 67
    S1_S28E; S28E, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. S28E protein is a component of the 30S ribosomal subunit. S28E is highly conserved among archaea and eukaryotes. S28E may control ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3E7X9.1

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