SEY1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SEY1
Primary source: SGD:S000005691
Locus tag: YOR165W
See related: AllianceGenome:SGD:S000005691; FungiDB:YOR165W; VEuPathDB:YOR165W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables GTPase activity. Involved in endoplasmic reticulum membrane fusion. Located in cortical endoplasmic reticulum. Used to study hereditary spastic paraplegia. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (644566..646896)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

reconstitution of a dynamic tubular membrane network with purified endoplasmic reticulum proteins; proteoliposomes containing the membrane-fusing GTPase Sey1p and the curvature-stabilizing protein Yop1p from Saccharomyces cerevisiae can form a tubular network upon addition of GTP
Title: Reconstitution of the tubular endoplasmic reticulum network with purified components.
we identify a NE role in Saccharomyces cerevisiae for Lnp1 and Sey1, proteins required for proper cortical ER formation.
Title: Nuclear pore complex integrity requires Lnp1, a regulator of cortical endoplasmic reticulum.
Endoplasmic reticulum -associated retrograde SNAREs and the Dsl1 complex mediate an alternative, Sey1p-independent homotypic endoplasmic reticulum fusion pathway.
Title: ER-associated retrograde SNAREs and the Dsl1 complex mediate an alternative, Sey1p-independent homotypic ER fusion pathway.
Sey1p is required indirectly for nuclear fusion
Title: ER-associated SNAREs and Sey1p mediate nuclear fusion at two distinct steps during yeast mating.
Propose that Lnp1p and Sey1p act antagonistically to balance endoplasmic reticular polygonal network formation.
Title: ER network formation requires a balance of the dynamin-like GTPase Sey1p and the Lunapark family member Lnp1p.
results show that Sey1p and its homologues function analogously to atlastins in mediating endoplasmic reticulum fusion
Title: The dynamin-like GTPase Sey1p mediates homotypic ER fusion in S. cerevisiae.
The Sey1p GTPase in S. cerevisiae is likely a functional ortholog of the atlastins; it shares the same signature motifs and membrane topology and interacts genetically and physically with the tubule-shaping proteins
Title: A class of dynamin-like GTPases involved in the generation of the tubular ER network.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum membrane fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum membrane fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in endoplasmic reticulum membrane fusion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endoplasmic reticulum membrane fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum organization	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in membrane organization	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in cellular bud	HDA more info	PubMed
located_in cortical endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dynamin-like GTPase SEY1

NP_014808.1

Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

644566..646896

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183584.1 → NP_014808.1 TPA: dynamin-like GTPase SEY1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014808.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B5VS52, D6W2M3, Q99287

UniProtKB/TrEMBL

C7GN59, C8ZGS6, N1NYJ0

Conserved Domains (1) summary

pfam05879
Location:43 → 681

RHD3; Root hair defective 3 GTP-binding protein (RHD3)