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RGA1 GTPase-activating protein RGA1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854294, updated on 2-Nov-2024

Summary

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Official Symbol
RGA1
Official Full Name
GTPase-activating protein RGA1
Primary source
SGD:S000005653
Locus tag
YOR127W
See related
AllianceGenome:SGD:S000005653; FungiDB:YOR127W; VEuPathDB:YOR127W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DBM1; THE1
Summary
Enables GTPase activator activity. Involved in several processes, including axial cellular bud site selection; budding cell apical bud growth; and cytoskeleton organization. Located in cellular birth scar; cellular bud neck split septin rings; and cellular bud scar. Orthologous to several human genes including ARHGAP12 (Rho GTPase activating protein 12) and ARHGAP27 (Rho GTPase activating protein 27). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RGA1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (561170..564193)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene putative monooxygenase CAT5 Neighboring gene isoamyl acetate-hydrolyzing esterase Neighboring gene phosphoribosylaminoimidazole carboxylase ADE2 Neighboring gene Afi1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Up-regulation of the Cdc42 GTPase limits the replicative life span of budding yeast. Kang PJ, et al. Mol Biol Cell, 2022 Apr 1. PMID 35044837, Free PMC Article
  2. Adjacent positioning of cellular structures enabled by a Cdc42 GTPase-activating protein-mediated zone of inhibition. Tong Z, et al. J Cell Biol, 2007 Dec 31. PMID 18166650, Free PMC Article
  3. The LIM domain-containing Dbm1 GTPase-activating protein is required for normal cellular morphogenesis in Saccharomyces cerevisiae. Chen GC, et al. Mol Cell Biol, 1996 Apr. PMID 8657111, Free PMC Article
  4. Regulation of Cdc42 polarization by the Rsr1 GTPase and Rga1, a Cdc42 GTPase-activating protein, in budding yeast. Lee ME, et al. J Cell Sci, 2015 Jun 1. PMID 25908844, Free PMC Article
  5. The GTPase-activating protein Rga1 interacts with Rho3 GTPase and may regulate its function in polarized growth in budding yeast. He F, et al. PLoS One, 2015. PMID 25860339, Free PMC Article

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables GTPase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axial cellular bud site selection IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in budding cell apical bud growth IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in budding cell isotropic bud growth IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in establishment of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in invasive growth in response to glucose limitation IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of pseudohyphal growth IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in response to pheromone IEA
Inferred from Electronic Annotation
more info
  
involved_in septin ring organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in septin ring organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in small GTPase-mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cellular birth scar IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cellular bud IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cellular bud IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud neck HDA PubMed 
located_in cellular bud neck split septin rings IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud scar IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
is_active_in mating projection tip IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
GTPase-activating protein RGA1
NP_014770.1
  • GTPase-activating protein for polarity-regulator Cdc42p (RhoGAP); required for proper bud site selection; transiently localizes to previous cell division sites (bud scars; cytokinesis remnants), interacting with Nis1p and Nba1p, to prevent Cdc42p repolarization; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from the bud neck to cytoplasm upon DNA replication stress; contains N-terminal LIM domains and a C-terminal GAP domain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    561170..564193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183546.1 → NP_014770.1  TPA: GTPase-activating protein RGA1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014770.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2I5, P39083, P39934
    UniProtKB/TrEMBL
    A6ZNX4, C7GML2, N1NWM0
    Conserved Domains (4) summary
    cd09394
    Location:13 → 67
    LIM1_Rga; The first LIM domain of Rga GTPase-Activating Proteins
    cd09395
    Location:70 → 123
    LIM2_Rga; The second LIM domain of Rga GTPase-Activating Proteins
    smart00324
    Location:803 → 1002
    RhoGAP; GTPase-activator protein for Rho-like GTPases
    COG1196
    Location:569 → 673
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39083.1

Gene LinkOut

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